Effects of Nitric Oxide on Skin Burn Wound Healing

    September 2008 in “ Journal of Burn Care & Research ”
    Haifeng Zhu, Xiaofei Wei, Ka Bian, Ferid Murad
    Image of study
    TLDR Nitric oxide gel helps heal skin burns faster by improving skin growth, hair regrowth, and blood vessel formation.
    The document from 2008 details a study on the impact of topical nitric oxide (NO) on second-degree burn wound healing in mice. The study demonstrated that NO treatment significantly improved wound healing by accelerating re-epithelialization by 50%, enhancing hair follicle regeneration, increasing the number of procollagen-expressing fibroblasts, and boosting angiogenesis. The NO gel also promoted the infiltration and retention of inflammatory cells in the wound bed, which are crucial for the release of growth factors and cytokines during healing. The study's findings, based on histological and immunohistochemical analyses, suggest that NO released from a topical gel could be a potential therapeutic agent for enhancing burn wound healing by regulating various cellular processes in the skin.
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