Effects of Nitric Oxide on Skin Burn Wound Healing

The document from 2008 details a study on the impact of topical nitric oxide (NO) on second-degree burn wound healing in mice. The study demonstrated that NO treatment significantly improved wound healing by accelerating re-epithelialization by 50%, enhancing hair follicle regeneration, increasing the number of procollagen-expressing fibroblasts, and boosting angiogenesis. The NO gel also promoted the infiltration and retention of inflammatory cells in the wound bed, which are crucial for the release of growth factors and cytokines during healing. The study's findings, based on histological and immunohistochemical analyses, suggest that NO released from a topical gel could be a potential therapeutic agent for enhancing burn wound healing by regulating various cellular processes in the skin.