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Glossary Re-epithelialization

process of new skin cell growth over a wound

Re-epithelialization is the process by which new skin cells (epithelial cells) grow and cover a wound, helping it to heal. This is a crucial step in wound healing, as it restores the protective barrier of the skin, preventing infection and further injury. For professionals, it involves the migration, proliferation, and differentiation of keratinocytes to re-establish the epidermal layer.

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research Re-epithelialization of the skin following CO 2 laser resurfacing

20 citations , January 2001 in “Journal of Cutaneous Laser Therapy”

This study found that wound healing after CO(2) laser resurfacing is faster with occlusive dressings, as they enhance cell migration from hair follicles, compared to untreated skin, which showed delayed re-epithelialization.

research The efficacy and safety of autologous epidermal cell suspensions for re‐epithelialization of skin lesions: A systematic review and meta‐analysis of randomized trials

10 citations , June 2024 in “Skin Research and Technology”

This meta-analysis found that autologous epidermal cell suspensions reduce healing time, donor site size, operation time, pain scores, and complications in skin lesions. However, their impact on treatment area size, repigmentation, scar scale scores, and patient satisfaction was minimal.

research M-CSF-stimulated myeloid cells can convert into epithelial cells to participate in re-epithelialization and hair follicle regeneration during skin wound healing

December 2021

This study reports that in mice, CD11b+ myeloid cells can convert into epithelial cells, contributing to skin wound repair and hair follicle regeneration.

research Platelet-rich plasma accelerates skin wound healing by promoting re-epithelialization

169 citations , January 2020 in “Burns & Trauma”

In this study, autologous platelet-rich plasma improved skin wound healing in mice, associated with reduced inflammation and enhanced angiogenesis and re-epithelialization, but the underlying regulatory mechanism requires further investigation.

Thyroxine (T4) May Promote Re-Epithelialization and Angiogenesis in Wounded Human Skin Ex Vivo

research Thyroxine (T4) may promote re-epithelialisation and angiogenesis in wounded human skin ex vivo

27 citations , March 2019 in “PLoS ONE”

This study suggests that Thyroxine (T4) may promote key features of human skin wound healing, such as re-epithelialization and angiogenesis, in an ex vivo model.

research Nanoclay gels promote re-epithelialization and improve the quality of skin wound healing in a diabetic mouse model

July 2026 in “npj Regenerative Medicine”

This study found that applying Laponite clay gels to skin wounds in mice did not speed up wound closure but significantly improved healing quality compared to phosphate-buffered saline or alginate treatments, with benefits such as enhanced re-epithelialization and hair follicle stimulation near wounds.

Thyrotropin-Releasing Hormone Promotes Wound Re-Epithelialisation in Frog and Human Skin

research Thyrotropin-Releasing Hormone (TRH) Promotes Wound Re-Epithelialisation in Frog and Human Skin

46 citations , September 2013 in “PLOS ONE”

This study identified thyrotropin-releasing hormone (TRH) as a stimulant of wound healing in both frog and human skin models, suggesting it as a potential neuroendocrine wound repair promoter.

research 658 The epigenetic control of re-epithelialization during adult skin wound healing

July 2024 in “Journal of Investigative Dermatology”

research 1α,25-Dihydroxyvitamin D3 accelerates skin wound re-epithelialization by promoting epidermal stem cell proliferation and differentiation through PI3K activation: an in vitro and in vivo study

2 citations , January 2025 in “Brazilian Journal of Medical and Biological Research”

This study demonstrated that VD3 significantly enhanced the proliferation and differentiation of epidermal stem cells in a murine skin defect model, leading to improved wound healing, potentially through activation of the PI3K signaling pathway.

research M-CSF-stimulated myeloid cells can convert into epithelial cells to participate in re-epithelialization and hair follicle regeneration during dermal wound healing

June 2022 in “PLOS ONE”

In this study, researchers found that myeloid cells can convert into keratinocytes during wound healing and contribute to hair follicle regeneration in mice.

research Moist exposed burn ointment accelerates diabetes-related wound healing by promoting re-epithelialization

24 citations , January 2023 in “Frontiers in Medicine”

Moist Exposed Burn Ointment speeds up healing of diabetic wounds.

research Insight into Reepithelialization: How Do Mesenchymal Stem Cells Perform?

40 citations , December 2015 in “Stem Cells International”

This review discusses the roles that mesenchymal stem cells may play in reepithelialization of wounds, but reports no new clinical results.

Reepithelialization of a Full-Thickness Burn from Stem Cells of Hair Follicles Micrografted into a Tissue-Engineered Dermal Template (Integra)

research Reepithelialization of a Full-Thickness Burn from Stem Cells of Hair Follicles Micrografted into a Tissue-Engineered Dermal Template (Integra)

87 citations , February 2004 in “Plastic and Reconstructive Surgery”

In this study, researchers achieved complete reepithelialization and hair growth on a burn-injured scalp using a tissue-engineered dermal template with early micrograft hair follicle implantation.

research Epigenetic control of skin and hair regeneration after wounding

36 citations , July 2014 in “Experimental Dermatology”

This narrative piece considers how epigenetic factors may influence the processes of skin wound healing, including hair follicle formation, but it presents no new experimental results.

research Novel skin patch combining human fibroblast-derived matrix and ciprofloxacin for infected wound healing

49 citations , January 2018 in “Theranostics”

This study found that a novel skin patch combining extracellular matrix and ciprofloxacin promotes advanced wound healing and skin regeneration in mouse models of infected wounds.

Skin Regeneration with Conical and Hair Follicle Structure of Deep Second-Degree Scalding Injuries via Combined Expression of the EPO Receptor and Beta Common Receptor by Local Subcutaneous Injection of Nanosized rhEPO

research Skin regeneration with conical and hair follicle structure of deep second-degree scalding injuries via combined expression of the EPO receptor and beta common receptor by local subcutaneous injection of nanosized rhEPO

15 citations , March 2012 in “International journal of nanomedicine”

In this study, local injection of nanosized recombinant human erythropoietin at the injury site improved skin regeneration and re-epithelialization in a mouse model of deep second-degree burns through coexpression of specific receptors.

research MSC-EVs and UCB-EVs promote skin wound healing and spatial transcriptome analysis

12 citations , February 2025 in “Scientific Reports”

This study found that extracellular vesicles derived from mesenchymal stem cells and umbilical cord blood plasma enhanced wound healing and reduced scar formation in mice, suggesting their potential as therapeutic agents for skin repair.

research Regulatory T cells in skin regeneration and wound healing

3 citations , October 2023 in “Military Medical Research/Military medical research”

This review explores the crucial role of regulatory T cells in skin wound healing, emphasizing their involvement in balancing immune responses and promoting regeneration. It also discusses Tregs' operations in fibrosis, keloidosis, and scarring, suggesting a potential avenue for novel treatments.

research Distinct fibroblast lineages determine dermal architecture in skin development and repair

1235 citations , December 2013 in “Nature”

This study found that skin fibroblasts in mice arise from two distinct lineages which contribute differently to dermal structure and repair, impacting hair follicle formation during wound healing.

Activin Controls Skin Morphogenesis and Wound Repair Predominantly via Stromal Cells and in a Concentration-Dependent Manner via Keratinocytes

research Activin Controls Skin Morphogenesis and Wound Repair Predominantly via Stromal Cells and in a Concentration-Dependent Manner via Keratinocytes

81 citations , September 2005 in “The American journal of pathology”

This study found that activin affects both stromal cells and keratinocytes in skin morphogenesis and repair, with dose-dependent effects on keratinocytes demonstrated through transgenic mouse models.

Synergistic Effect of Bismuth Subgallate and Borneol on Skin Wound Healing

research Synergistic effect of bismuth subgallate and borneol, the major components of Sulbogin®, on the healing of skin wound

49 citations , April 2003 in “Biomaterials”

In this study, BS and BO combined showed a synergistic effect in enhancing wound healing in rat skin lesions compared to using either alone or Flamazine®.

research Optimal skin regeneration after full thickness thermal burn injury in the spiny mouse, Acomys cahirinus

39 citations , June 2018 in “Burns”

This study found that the spiny mouse can regenerate tissues such as skeletal muscle, dermis, and hair without scarring after full thickness thermal burns, unlike the lab mouse.

research Chitosan/LiCl composite scaffolds promote skin regeneration in full-thickness loss

24 citations , January 2019 in “Science China Life Sciences”

Chitosan/LiCl composite scaffolds help heal deep skin wounds better.

research Multi-faceted enhancement of full-thickness skin wound healing by treatment with autologous micro skin tissue columns

14 citations , January 2021 in “Scientific Reports”

This study found that "micro skin tissue columns" improved wound healing by enhancing re-epithelialization, collagen deposition, dermal remodeling, and reducing inflammation without causing long-term donor site morbidity.

Superiority of Occipital Donor Sites for Split-Thickness Skin Grafting in Dermatosurgery: Results of a Prospective Randomized Controlled Study

research Superiority of occipital donor sites for split‐thickness skin grafting in dermatosurgery: Results of a prospective randomized controlled study

7 citations , September 2017 in “Journal der Deutschen Dermatologischen Gesellschaft”

In this randomized controlled trial, occipital donor sites for split-thickness skin grafts showed superior re-epithelialization, reduced pain, fewer complications, and better cosmetic outcomes compared to femoral donor sites.

Combination of an Engineered Lactococcus Lactis Expressing CXCL12 with Light-Emitting Diode Yellow Light as a Treatment for Scalded Skin in Mice

research Combination of an engineered Lactococcus lactis expressing CXCL12 with light‐emitting diode yellow light as a treatment for scalded skin in mice

6 citations , July 2021 in “Microbial biotechnology”

This study found that combining LED yellow light with an engineered strain expressing CXCL12 improved wound healing and reduced inflammation in a mouse model of scald wounds.