The GPI-Anchored Protein Thy-1/CD90 Promotes Wound Healing by Enhancing Skin Perfusion

    October 2022 in “ International Journal of Molecular Sciences ”
    Leonardo A. Pérez, J. B. León, Juan C. López, Daniela Rojas, María Isabel Pávez Reyes, Pamela Contreras, Andrew F. G. Quest, Carlos Escudero, Lisette Leyton
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    TLDR Thy-1 protein helps improve blood flow and wound healing in the skin.
    The research investigated the role of the GPI-Anchored Protein Thy-1/CD90 in wound healing, focusing on its impact on skin perfusion. The study involved 18 wild type (WT) mice and 20 Thy-1 knockout (Thy-1−/−) mice. Results showed that the absence of Thy-1 delayed wound healing, impaired re-epithelialization, and decreased blood perfusion during the healing process. However, by day 14, wounds closed similarly in both WT and Thy-1−/− mice. The study concluded that Thy-1 enhances wound healing by promoting blood perfusion in the wounded area, making it a potential target for wound therapy.
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