Stem Cells from Human Exfoliated Deciduous Teeth Promote Hair Regeneration in Mice

In 2021, a study was conducted using stem cells from human exfoliated deciduous teeth (SHED) to promote hair regeneration. The SHED were extracted from children aged 8-12 years and co-transplanted with skin cells of C57 mice into nude mice. The study found that SHED could enhance hair growth, shorten the hair regeneration cycle, and stimulate the proliferation and aggregation of dermal cells. The SHED also upregulated the Sonic Hedgehog (Shh) and Glioma-associated oncogene 1 (Gli1) pathway, suggesting a mechanism for hair growth promotion. The researchers concluded that SHED could be a potential tool for tissue engineering and damaged tissue repair, but noted that further research was needed for clinical applications.