December 2023 in “Communications biology” This study found that inhibiting the HEDGEHOG-GLI1 pathway could reduce keloid size and gene expression, suggesting it as a potential therapeutic target for keloid pathogenesis.
May 2023 in “Research Square (Research Square)” This study observed that the Hedgehog-GLI1 signaling pathway is upregulated in keloid patient–derived stem cells, and inhibiting this pathway reduced keloid characteristics in both mice and ex vivo tissue cultures, suggesting potential therapeutic targets for keloid treatment.
This study found that recombinant human type XVII collagen (rhCOL17A1) promotes hair growth by activating the Wnt/β-catenin and SHH/GLI signaling pathways and increasing type XVII collagen expression, with significant effects observed in both cell and mouse models.
638 citations
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October 1997 in “Nature” 171 citations
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June 2004 in “Journal of Investigative Dermatology” GLI2 activates GLI1, promoting skin tumor growth and hair development.
