Trichoscopic Evaluation of Dental Pulp Stem Cell Conditioned Media for Androgenic Alopecia

The study evaluated the efficacy and safety of conditioned media (CM) derived from dental pulp stem cells obtained from human exfoliated deciduous teeth (SHED-CM) in treating androgenic alopecia. The study involved 88 male subjects with varying severity of androgenic alopecia, out of which 33 received six SHED-CM treatments at 1-month intervals. The results showed that SHED-CM was effective for 75% of subjects regardless of disease severity, concomitant use of dihydrotestosterone synthesis inhibitor (DHT-inhibitor), and age. Adverse effects were mild and transient. The study also found that a scoring system of three quantitative trichoscopic factors (maximum hair diameter, vellus hair rate, and multi-hair follicular unit rate) could potentially predict the efficacy of SHED-CM.