Trichoscopic Evaluation of Dental Pulp Stem Cell Conditioned Media for Androgenic Alopecia

May 2023 in “ PubMed ”

Tomoko Kamishima, Chie Hirabe, Takanori Ohnishi, Junichi Taguchi, Khin Zay Yar Myint, Shoji Koga

conditioned media dental pulp stem cells SHED-CM androgenic alopecia dihydrotestosterone synthesis inhibitor DHT-inhibitor trichoscopic evaluation maximum hair diameter vellus hair rate multi-hair follicular unit rate CM

TLDR Hair loss treatment using stem cells from baby teeth was effective for 75% of men tested, with mild side effects. A scoring system may predict how well this treatment works.

The study evaluated the efficacy and safety of conditioned media (CM) derived from dental pulp stem cells obtained from human exfoliated deciduous teeth (SHED-CM) in treating androgenic alopecia. The study involved 88 male subjects with varying severity of androgenic alopecia, out of which 33 received six SHED-CM treatments at 1-month intervals. The results showed that SHED-CM was effective for 75% of subjects regardless of disease severity, concomitant use of dihydrotestosterone synthesis inhibitor (DHT-inhibitor), and age. Adverse effects were mild and transient. The study also found that a scoring system of three quantitative trichoscopic factors (maximum hair diameter, vellus hair rate, and multi-hair follicular unit rate) could potentially predict the efficacy of SHED-CM.

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