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Did you mean Glioma-associated oncogene homolog 1?

GlossaryGLI1 (Glioma-associated oncogene homolog 1)

gene involved in cell growth and development signaling

GLI1, or Glioma-associated oncogene homolog 1, is a gene that encodes a protein involved in the Hedgehog signaling pathway, which is crucial for cell growth and development. Abnormal activation of GLI1 can lead to uncontrolled cell proliferation and is associated with various cancers, including gliomas.

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The Hedgehog-GLI1 Pathway Is Important for Fibroproliferative Properties in Keloids and as a Candidate Therapeutic Target

research The Hedgehog-GLI1 Pathway Is Important for Fibroproliferative Properties in Keloids and as a Candidate Therapeutic Target

December 2023 in “Communications biology”

Targeting the HEDGEHOG-GLI1 pathway could help treat keloids.

Epigallocatechin-3-Gallate Promotes the Growth of Mink Hair Follicles Through Sonic Hedgehog and Protein Kinase B Signaling Pathways

research Epigallocatechin-3-Gallate Promotes the Growth of Mink Hair Follicles Through Sonic Hedgehog and Protein Kinase B Signaling Pathways

14 citations, June 2018 in “Frontiers in pharmacology”

Green tea compound EGCG helps mink hair follicles grow by affecting certain cell growth pathways.

Phase I Study of the Hedgehog Pathway Inhibitor IPI-926 in Adult Patients with Solid Tumors

research Phase I Study of the Hedgehog Pathway Inhibitor IPI-926 in Adult Patients with Solid Tumors

136 citations, April 2013 in “Clinical Cancer Research”

The drug IPI-926 is safe at 160 mg daily and may help treat certain tumors, especially basal cell carcinoma.

research Coactivator MED1 Ablation in Keratinocytes Results in Hair-Cycling Defects and Epidermal Alterations

41 citations, April 2012 in “The journal of investigative dermatology/Journal of investigative dermatology”

Deleting MED1 in skin cells causes hair loss and skin changes.

research Alpinetin Promotes Hair Regeneration via Activating Hair Follicle Stem Cells

11 citations, May 2022 in “Chinese medicine”

Alpinetin helps grow hair by turning on hair stem cells and is safe for use.

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