30 citations
,
February 2022 in “Pharmaceutics” This review explores recent advancements in skin tissue engineering using 3D bioprinting, discussing current methods, bioink formulations, and outlining both achievements and limitations without presenting new clinical results.
30 citations
,
December 2014 in “BMC Genetics” This study found thousands of differentially expressed genes and proteins that may be associated with wool growth, suggesting potential gene families involved in hair growth regulation.
26 citations
,
March 2014 in “Rheumatology” This study confirms an association between TNF-α antagonist exposure and alopecia, indicating a class effect among the medications examined.
24 citations
,
February 2022 in “Journal of Biological Chemistry” This study found that carvacrol activates the TRPV3 ion channel by binding to a specific pocket formed by the S2-S3 linker, providing insight into its role in skin sensitization and potential for designing specific modulators.
24 citations
,
July 2015 in “International Journal of Molecular Sciences” In this study, fluoxetine was found to decrease proliferation and adipogenic differentiation of human adipose-derived stem cells, suggesting it may reduce fat accumulation by increasing autophagy-related gene expression.
22 citations
,
November 2018 in “Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry” This study reviewed the initial clinical presentation of SLE patients in Oman, revealing diverse symptoms and highlighting the importance of nationwide collaboration for effective management of the condition.
22 citations
,
June 2017 in “Stem cell reports” This study found that PTEN regulates the number and genomic stability of hair follicle stem cells in the skin, with its deficiency leading to increased stem cell accumulation and senescence through interactions with BMAL1 and BMI-1.
22 citations
,
April 2012 in “The American journal of pathology” This study found that the loss of Msx2 in knockout mice led to phenotypes similar to Peters anomaly and microphthalmia, suggesting that MSX2 plays a critical role in anterior segment development of the eye.
20 citations
,
December 2021 in “Plants” This review concludes that Tamarix aphylla, used traditionally for ailments such as tuberculosis and hepatitis, demonstrates various pharmacological activities, including antidiabetic and wound-healing effects, but stresses the need for further research to confirm its safety and effectiveness in humans.
19 citations
,
November 2018 in “Experimental Dermatology” This review explores the skin regeneration process in spiny mice and highlights differences from laboratory mice, focusing on potential molecular and immune system roles without reporting new experimental results.
18 citations
,
October 2022 in “Biomedicines” This review discusses the role of anti-Müllerian hormone in polycystic ovary syndrome and its male equivalent, but reports no new clinical findings; it suggests further investigation is needed into male relatives' reproductive function.
18 citations
,
January 2022 in “Nutrients” This review discusses potential agents, including acetyl-L-carnitine and vitamins, for repurposing in managing chemotherapy-induced peripheral neuropathy and reports no clinical results; the authors emphasize the need for further research.
18 citations
,
August 2015 in “Biochemical and Biophysical Research Communications” This study found that the XEDAR receptor can activate the non-canonical NF-kB pathway involving p100 processing, which is regulated by interactions with TRAF proteins and specific kinases.
17 citations
,
September 2024 in “Journal of Ginseng Research” This review discusses recent in vitro and in vivo research suggesting that components of ginseng, such as ginsenosides and gintonin, may have potential skincare benefits, including anti-aging effects and treatment of skin conditions like atopic dermatitis and hypertrophic scars.
17 citations
,
November 2000 in “Journal of Investigative Dermatology” ZPK helps skin cells mature and may affect skin health.
15 citations
,
June 2021 in “Medicina” This study found that combined intense pulsed light and low-level light therapy significantly improved ocular surface outcomes and quality of life for patients with meibomian gland dysfunction and dry eye disease.
15 citations
,
October 2020 in “European journal of pharmaceutics and biopharmaceutics” This study reported that combining microdialysis and selective follicular closure with varnish significantly reduces caffeine penetration through hair follicles in an ex vivo porcine ear skin model.
14 citations
,
May 2022 in “Asian Journal of Pharmaceutical Sciences” This review article highlights how hair follicle-targeting drug delivery systems enhance therapeutic outcomes and reduce side effects for treating conditions like androgenetic alopecia and acne vulgaris. The authors discuss current formulations and evaluate their performance in both preclinical and clinical settings.
14 citations
,
July 2016 in “Environmental Toxicology and Pharmacology” In this animal study, cedrol treatment reduced chemotherapy-induced alopecia in mice by preventing hair follicle damage, while minoxidil did not prevent alopecia under similar conditions.
13 citations
,
June 2020 in “International Journal of Molecular Sciences” This study found that the humanin analogue HNG significantly promoted hair growth in vitro and in vivo by prolonging the anagen phase and inhibiting hair follicle cell apoptosis in mice.
12 citations
,
September 2023 in “Polymers” This study reported that a newly developed hydrogel composed of recombinant type I collagen and chitosan, incorporating a metal–polyphenol structure, demonstrated strong mechanical and healing properties, effectively promoting wound healing in a full-thickness skin defect model.
12 citations
,
October 2018 in “Biotechnology reports” In this study, researchers reported that the application of refolded human K31 keratin protein significantly improved diameter, mechanical strength, and smoothness of chemically damaged hair after a single treatment.
11 citations
,
June 2024 in “Molecules” This review investigated the phytochemical variations in different medicinal parts of the plant *Alpinia zerumbet*, finding distinct chemical compositions between leaves, rhizomes, fruits, seeds, and flowers, which supports the traditional use of these parts for various medicinal purposes.
11 citations
,
November 2023 in “Journal of Functional Biomaterials” This study investigated nanocomposite scaffolds made from alginate, chitosan, and graphene oxide to promote the proliferation of spermatogonial stem cells, finding the ALGCS/GO30 scaffold to be particularly effective due to increased proliferation markers and PLZF protein expression compared to controls.
11 citations
,
November 2021 in “International journal of molecular sciences” In this study, germ-free male mice showed altered levels of certain neuroactive steroids in the brain and periphery, suggesting microbiota may influence neuroendocrine pathways that support brain functioning.
11 citations
,
February 2013 in “Clinical Endocrinology” This study found that the prevalence of hyperprolactinaemia in healthy premenopausal female blood donors is low and not affected by hormonal contraceptive use, with stress-related factors being the most common cause.
10 citations
,
September 2023 in “Metabolites” This study reviews iron metabolism in the skin, highlighting how differentially expressed genes regulate iron recycling in the epidermis, and discusses changes in iron metabolism related to skin diseases.
10 citations
,
November 2021 in “Biomedicines” This review describes and compares the efficacy of bioregenerative therapies, specifically mesenchymal stem cells and platelet-rich plasma, for treating osteoarthritis, suggesting they may offer a less invasive and more effective alternative to surgery and conventional therapies.
10 citations
,
November 2016 in “International Journal of Cosmetic Science” This study proposed the existence of a membrane-like structure between the cuticle and cortex in human hair, which may provide strong protection against external stimuli.
9 citations
,
December 2022 in “Antibiotics” This study found that coconut seed extract may effectively treat scabies in rabbits by improving infection signs and causing high mite mortality, suggesting its potential as a cost-effective herbal alternative.