Systemic Lupus Erythematosus: Symptoms and Signs at Initial Presentations

November 2018 in “ Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry ”

Abdel Masieh Metry, Issa Al Salmi, Farida Al Balushi, Mohammed Abdalla Yousef, Faisal Al Ismaili, Alan Hola, Suad Hannawi

Systemic Lupus Erythematosus SLE malar rash photosensitivity discoid lupus hair loss arthralgia myalgia lupus skin rash sun sensitivity hair thinning joint pain muscle pain

TLDR Most patients with Systemic Lupus Erythematosus experience fatigue, skin issues, and joint pain.

The study reviewed medical records of 966 patients diagnosed with Systemic Lupus Erythematosus (SLE) at the Royal Hospital in Oman from 2006 to 2014, finding that the majority were female (88.7%) with a mean age of 27.6 years. Common initial symptoms included fatigue (35.22%) and weight changes (13.43%), with prevalent cutaneous manifestations such as hair loss (39.29%), malar rash (37.69%), and photosensitivity (35.10%). Musculoskeletal issues like arthralgia (68.75%) and myalgia (55.65%) were also frequent. The study emphasized the need for nationwide and regional collaboration to improve SLE reporting and management. Additionally, the document reviewed various studies on SLE's initial presentations, highlighting diverse clinical manifestations and the importance of early diagnosis and tailored treatment strategies.

View this study on eurekaselect.com →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

research Clinical Presentation and Management Outcome of Childhood-Onset Systemic Lupus Erythematosus in Baghdad

13 citations, May 2014 in “PubMed”

Most children with childhood-onset lupus in Baghdad responded well to treatment, but some developed chronic kidney disease or died.

research Systemic Lupus Erythematosus (SLE) in the Eastern Region of Saudi Arabia: A Comparative Study

33 citations, August 2013 in “Lupus”

SLE patients in eastern Saudi Arabia have a generally good prognosis despite multi-organ involvement.

Cross-Sectional Study of Hair Loss Patterns in 122 Korean Systemic Lupus Erythematosus Patients: A Frequent Finding of Non-Scarring Patch Alopecia

research Cross-Sectional Study of Hair Loss Patterns in 122 Korean Systemic Lupus Erythematosus Patients: A Frequent Finding of Non-Scarring Patch Alopecia

34 citations, June 2007 in “The Journal of Dermatology”

Most Korean systemic lupus erythematosus patients experienced hair loss, often as non-scarring diffuse hair loss, with non-scarring patch alopecia also common.

Related Community Posts Join

6 / 992 results

community Hair Remedies that Don't Work for Anybody Seeking Hair Regrowth

in Treatment 7 upvotes 4 years ago

Hair loss treatments discussed include minoxidil, finasteride, and RU58841. Salon products and supplements generally don't work for hair regrowth unless there's a severe nutritional deficiency, while hormonal treatments like estrogen and spironolactone can be effective.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community 2024 guide for male pattern baldness: 10 take home messages from Dr. Moreno-Arrones

in Research/Science 243 upvotes 1 month ago

Effective treatments for male pattern baldness include finasteride, dutasteride, and oral minoxidil. Non-effective approaches include oils, shampoos, serums, laser therapies, massages, vitamins, and microneedling.

community Minoxidil Finasteride heart problems

in Update 97 upvotes 6 months ago

A user experienced heart problems after taking 1mg finasteride and 2.5mg oral minoxidil and is considering quitting minoxidil. Others discussed their experiences with heart issues and minoxidil, with some suggesting topical minoxidil as a safer alternative.

community Seeking Advice: Unusual Hair Loss at 31 Years Old - Any Insights? (M)

in Chat 15 upvotes 7 months ago

A 31-year-old man who previously had good results with minoxidil, finasteride, and nizoral for hair loss is now experiencing unusual hair loss and side effects from finasteride. Respondents suggest it might be severe retrograde alopecia and recommend exploring other treatment options due to his inability to tolerate finasteride.

community A Systemic Review on Topical Marketed Formulations, Natural Products, and Oral Supplements to Prevent Androgenic Alopecia: A Review

in Research/Science 6 upvotes 5 months ago

Topical formulations, natural products, and CAM therapies are being used to treat Androgenic alopecia to avoid side effects of Finasteride and Minoxidil. The review covers various low-risk, alternative treatment options.

Related Research

2 / 2 results

research Clinico-Pathological Profile of Cutaneous Lupus Erythematosus Patients: A Report from a Tertiary Care Center of Chattogram

November 2021 in “Chattagram Maa-O-Shishu Hospital Medical College Journal”

Most patients with Cutaneous Lupus Erythematosus are young females, and dermatologists play a key role in diagnosis.

research Tumid Lupus Erythematosus and Systemic Lupus Erythematosus: A Report on Their Rare Coexistence

6 citations, April 2020 in “Cureus”

A woman with both TLE and SLE improved with hydroxychloroquine treatment.