Cell and Cell-Free Therapies in Osteoarthritis

November 2021 in “ Biomedicines ”

Pau Peláez, E Damia, Marta Torres-Torrillas, Déborah Chicharro, Belén Cuervo, Laura De Miguel, Ayla Del Romero, José M. Carrillo, Joaquín Sopena, Mónica Rubio

platelet-rich plasma PRP

TLDR Some therapies using stem cells and platelet-rich plasma may help treat osteoarthritis, but more research is needed to ensure they are safe and effective.

The document discusses the potential of cell and cell-free therapies in treating osteoarthritis. It emphasizes the role of mesenchymal stem cells (MSCs) and adipose-derived stem cells (ADSCs) in promoting cartilage regeneration and slowing osteoarthritis progression. The use of platelet-rich plasma (PRP) in knee osteoarthritis treatment is also mentioned. However, the effectiveness of these therapies can be influenced by factors like the donor's age and the stem cells' source. The document also discusses the use of autologous uncultured adipose-derived stromal cells in inhibiting cartilage degeneration. While these therapies show promise, more research is needed to confirm their safety and efficacy.

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