56 citations
,
August 1994 in “PubMed” This study found that prolactin and melatonin both stimulated hair shaft elongation in Cashmere goat hair follicles, with maximum growth observed at specific concentrations, although melatonin reduced follicle viability after 96 hours.
55 citations
,
June 1987 in “PubMed” In this study, cyclosporin A treatment significantly increased hair length in nude mice compared to controls, but hair growth reversed after treatment stopped.
55 citations
,
March 1973 in “PubMed” Minoxidil is a new drug that lowers blood pressure.
54 citations
,
December 2004 in “PubMed” This study suggests that topical Cyclosporin A formulations, with or without a penetration enhancer, effectively stimulated hair regrowth in a rat model of alopecia areata.
54 citations
,
September 1999 in “PubMed” This study suggests that immunostaining for Keratin 15 may be a useful tool for differentiating between basal cell carcinoma and trichoepithelioma.
53 citations
,
May 2010 in “PubMed” This paper discusses spironolactone as a potential off-label treatment for female pattern hair loss, noting its ability to halt hair loss progression and induce partial regrowth in a significant number of women but reports no new clinical results.
52 citations
,
July 2011 in “PubMed” This review discusses the diverse roles of the TRPS1 gene in regulating cartilage, kidney, and hair follicle development, highlighting its functions and interactions, but provides no new experimental results.
52 citations
,
January 2005 in “PubMed” This study concluded that alpha(1)-adrenoceptor antagonists are more effective than finasteride in the short term for reducing symptoms of lower urinary tract symptoms associated with benign prostatic hyperplasia.
51 citations
,
January 1997 in “PubMed” This review outlines the genetic basis of GABEB, highlighting reduced type XVII collagen as a distinguishing marker from Herlitz JEB, and discusses potential therapeutic avenues without presenting new results.
50 citations
,
January 2007 in “PubMed” This review discusses female pattern hair loss, highlighting that while oral antiandrogens and topical minoxidil can arrest progression, early diagnosis and treatment are crucial, and stresses the need for ongoing therapy.
50 citations
,
July 2001 in “PubMed” This study suggests a potential link between early-onset baldness before age 30 and increased risk for coronary artery disease, warranting consideration in epidemiological research.
50 citations
,
March 1992 in “PubMed” This review discusses the clinical manifestations of malnutrition in children, particularly highlighting the overlapping skin changes from various nutrient deficiencies, and reports no new clinical results.
49 citations
,
October 2022 in “PubMed” This review examines alopecia, its causes, the impact of micronutrients, and the role of the Mediterranean diet, noting conflicting data and a need for more research on diet's effect on hair loss.
49 citations
,
March 2017 in “PubMed” This review discusses the role of enhancers and super-enhancers in tissue-specific gene regulation and cancer development, and it reports no new experimental results.
48 citations
,
September 2010 in “PubMed” This review discusses chemotherapy-induced hair loss, highlighting that topical minoxidil can lessen its severity or duration but not prevent it, and reports no new clinical results.
48 citations
,
March 2005 in “PubMed” This paper reviews the potential of various bioactive plant compounds, including resveratrol and curcumin, for modulating angiogenesis but presents no new clinical results.
48 citations
,
February 1999 in “PubMed” This study found that the anticonvulsant effects of progesterone against PTZ-induced seizures in mice require conversion to allopregnanolone, as shown by the reversal of these effects with a 5alpha-reductase inhibitor.
48 citations
,
April 1995 in “PubMed” This study found that dermal papilla cells from beard and axillary hair follicles can produce androgen-dependent factors that stimulate proliferation in adjacent follicular epithelial cells under testosterone influence.
48 citations
,
July 1988 in “PubMed” In this study, researchers observed that rhino mice exhibit significant ductal hyperkeratinization in the meibomian gland, which may represent the first naturally occurring disorder of this gland in mice.
48 citations
,
June 1988 in “PubMed” In this study, minoxidil sulfate was found to relax norepinephrine-induced contractions in rabbit mesenteric arteries, possibly by acting as a K+ channel agonist, but it did not relax K+-induced contractions.
46 citations
,
December 2010 in “PubMed” This study demonstrated that tocotrienol supplementation increased hair number in individuals with hair loss compared to a placebo, likely due to its antioxidant effects.
46 citations
,
August 2006 in “PubMed” In this study, researchers identified and examined males with 17 beta-HSD3 deficiency in a highly inbred Arab population, noting genetic findings and the progression of male characteristics despite being raised as females initially.
46 citations
,
January 2005 in “PubMed” This paper discusses risk factors and prevention strategies for acute urinary retention secondary to benign prostatic hyperplasia, emphasizing the role of PSA levels and the benefits of medications like finasteride and alpha-blockers, but reports no new clinical results.
46 citations
,
January 1988 in “PubMed” This study found that Demodex mites may transport Microsporum canis spores on human skin, suggesting a potential role in microbial movement despite typically being considered harmless.
45 citations
,
August 1992 in “PubMed” In this study, researchers found that changes in the extracellular matrix components, particularly fibronectin, laminin, and type IV collagen, during the rat vibrissa follicle growth cycle, suggest dynamic remodeling related to dermal-epidermal signaling.
44 citations
,
April 2015 in “PubMed” This study reports that clinical trials of finasteride for androgenic alopecia provide insufficient and systematically biased safety data, with most participants unrepresentative of those in pivotal trials that led to FDA approval.
44 citations
,
May 1998 in “PubMed” In this study, a specific retinoic acid receptor antagonist caused severe craniofacial anomalies in mouse fetuses when administered early in pregnancy, but not limb anomalies, highlighting developmental stage-specific roles of retinoic acid.
44 citations
,
August 1990 in “PubMed” This study provides evidence for K1 and K10 derivatives' presence in the inner root sheath and hair cuticle, suggesting that these hair follicle parts may follow familiar keratinization principles.
43 citations
,
January 2006 in “PubMed” This article summarizes findings on the role of androgens and estrogens in male reproductive tissues across species, highlighting the roles of hormone metabolism, receptor distribution, and stress-induced changes.
42 citations
,
July 1982 in “PubMed” This study found that a low estrogen-containing oral contraceptive normalized hormone levels and improved symptoms in women with polycystic ovary disease, with minimal side effects reported.