42 citations
,
December 1976 in “PubMed” This study found that the combination of cyproterone acetate and ethinyl estradiol improved hirsutism and acne in women, with SH 8.1041 showing significant results and both treatments being generally well-tolerated.
41 citations
,
July 2001 in “PubMed” This study reported that while finasteride and progesterone significantly inhibited dihydrotestosterone synthesis in dermal papillae, estrogens were less effective.
41 citations
,
May 2001 in “PubMed” This study proposes a new clinical scoring method for hair density based on hair diameter diversity, which correlates with existing measures and reflects follicle miniaturization in androgenetic alopecia.
40 citations
,
May 2018 in “PubMed” In this randomized, double-blind, placebo-controlled study, daily use of the Nutrafol® Women's Capsules nutraceutical significantly increased the number of terminal and vellus hairs and improved hair quality in women with self-perceived thinning over six months, without any reported adverse events.
39 citations
,
November 2017 in “PubMed” This case series reported that low-dose naltrexone may benefit patients with lichen planopilaris by reducing scalp symptoms and slowing disease progression, with no adverse effects observed in the patients.
39 citations
,
January 2016 in “PubMed” This review discusses the role of epidermal differentiation complex genes and epigenetic mechanisms in skin development and certain diseases, emphasizing their potential for improving drug development and delivery systems but provides no new experimental results.
38 citations
,
June 2015 in “PubMed” This study found that topical calcipotriol may safely and effectively treat mild-to-moderate patchy alopecia areata, with significant hair regrowth observed in the majority of participants over 12 weeks.
38 citations
,
January 2011 in “PubMed” This review discusses the range of cutaneous side-effects caused by EGFR inhibitors in cancer therapy and explores available treatment options, without reporting new clinical findings.
38 citations
,
January 2005 in “PubMed” This study found that dutasteride effectively improves symptoms of benign prostatic hyperplasia, showing benefits in urinary flow and quality of life, with only modestly elevated sexual side effects compared to placebo.
38 citations
,
January 1993 in “PubMed” This article discusses the impact of minoxidil on legitimizing scientific research in common baldness and reports no new clinical findings.
38 citations
,
May 1982 in “PubMed” This report describes almost complete resolution of calcinosis and healing of associated ulcers in an 83-year-old woman with localized scleroderma after repeated intralesional steroid injections.
37 citations
,
February 2008 in “PubMed” This article reviews radiation-induced cicatricial alopecia and suggests that controlling radiation dose depth could potentially prevent this condition.
37 citations
,
May 2002 in “PubMed” In this study, long-term use of finasteride did not negatively impact bone mineral density in men with benign prostatic hyperplasia over a 4-year period.
37 citations
,
January 1980 in “PubMed” This study found that topical hair lotions with 17 alpha-estradiol may reduce telogen hair loss in patients with androgenetic alopecia, though they did not lead to new hair regrowth.
36 citations
,
June 2012 in “PubMed” This review discusses various treatments for androgenetic alopecia, including minoxidil, finasteride, dutasteride, ketoconazole, and experimental options, but reports limited clinical trial evidence for efficacy.
36 citations
,
August 2009 in “PubMed” This article discusses different types of hair loss, their potential causes, and treatment options, but it reports no new clinical findings; the authors emphasize the importance of considering the emotional impact on patients.
36 citations
,
September 1996 in “PubMed” This study found that dermal papilla and dermal sheath cells from human scalp tissue differ from interstitial dermal fibroblasts in morphology and produce varying levels of TGF-beta 2.
36 citations
,
April 1994 in “PubMed” This study introduces a mouse model of cyclophosphamide-induced alopecia, which effectively replicates human chemotherapy-induced hair loss and can be pharmacologically manipulated to study hair regrowth patterns.
36 citations
,
January 1991 in “PubMed” In this pilot study, 2% topical Minoxidil showed no benefit in preventing hair loss during chemotherapy for gynecologic cancers, although it was non-toxic.
35 citations
,
September 2017 in “PubMed” This article reviews different types of alopecia, their diagnosis, and treatment options available in a family physician's practice, but it reports no new research findings.
35 citations
,
December 2008 in “PubMed” In this study, researchers reported that specific immunoreactivity patterns observed in hair follicle stem cell markers suggest different origins for trichilemmoma, basal cell carcinoma, and squamous cell carcinoma in human skin tissues.
35 citations
,
April 1998 in “PubMed” This study found that activating the erbB-2 oncogene in transgenic mice led to severe skin abnormalities and fatal defects, indicating erbB-2's significant role in skin and hair follicle development.
35 citations
,
January 1990 in “PubMed” This study found that oral cyclosporin A increased hair growth in nude mice, while minoxidil did not have the same effect.
35 citations
,
July 1977 in “PubMed” This case report describes a woman with systemic lupus erythematosus who developed both pneumonitis and nephritis, with identical immune complexes found in her lungs and kidneys, suggesting a common pathogenetic mechanism.
34 citations
,
April 2006 in “PubMed” This review discusses current treatments for benign prostatic hyperplasia and reports on the cost-effectiveness of alpha1-selective adrenergic receptor antagonists compared to other pharmacologic and invasive therapies without presenting new clinical results.
34 citations
,
January 2004 in “PubMed” In this study, finasteride treatment for 56 days in adult rats led to sloughing of immature germinal cells and reduced sperm content in the epididymis, indicating its importance for maintaining spermatogenesis.
34 citations
,
April 2001 in “PubMed” This study found that eflornithine HCl 13.9% cream reduces unwanted facial hair growth in women, with effects seen in up to 60% of participants over 4-8 weeks, with mostly minor skin irritation reported.
34 citations
,
October 1998 in “PubMed” This article reviews the role of stem cells and cytokines in hair growth and discusses existing and potential treatments, but it presents no new clinical data.
34 citations
,
July 1993 in “PubMed” This article reviews the characteristics and uses of finasteride for benign prostatic hyperplasia, noting variable symptom improvement and ongoing investigation in other DHT-mediated conditions, and reports no new clinical results.
33 citations
,
October 2005 in “PubMed” In this case study, significant improvement in androgenic alopecia was observed in a 46-year-old woman after 9 months of treatment with dutasteride following limited success with finasteride.