Cicatricial Alopecia Secondary to Radiation Therapy: Case Report and Review of the Literature

    February 2008 in “ PubMed ”
    Gregg A Severs, Thomas D. Griffin, Maria Werner‐Wasik
    TLDR Keeping radiation doses under 16 Gy may reduce permanent hair loss.
    The document discussed cicatricial alopecia resulting from high-dose radiation therapy (RT) used for treating intracranial malignancies, which led to permanent destruction of hair follicles and alopecia. A case was reported where radiation-induced cicatricial alopecia was confirmed by histopathology, but without obvious clinical scarring or dermal fibrosis, making the patient a suitable candidate for hair transplantation. The study suggested that if the radiation dose is kept under 16 Gy at a depth of 5 mm, the incidence of radiation-induced cicatricial alopecia could be reduced. A review of literature on this condition and current radiation methods was also included.
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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 3 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

      community Losing Hair on Dutasteride? You might have LPP

      in Research/Science  94 upvotes 8 months ago
      Men with hair loss might have lichen planopilaris (LPP), which can mimic androgenetic alopecia, leading to misdiagnosis and ineffective treatment with finasteride or dutasteride. Proper diagnosis, including biopsies, is crucial to distinguish between androgenetic alopecia and conditions like LPP.

      community Quote from Pelage (PP-405) Spokesperson...

      in Research/Science  121 upvotes 1 month ago
      Pelage is developing a topical hair follicle stem cell therapy, PP405, for non-scarring alopecias like androgenetic alopecia, with Phase III trials planned and a potential market launch by 2027. The treatment may not require continuous use after initial regrowth.

      community Totally confused by doctors opinions, would appreciate some clarity

      in Treatment  1 upvotes 11 months ago
      The user is experiencing hair loss and confusion over conflicting medical advice, with treatments including minoxidil, finasteride, and topical corticosteroids. They are unsure about the necessity of a biopsy and the timing of using minoxidil, while also considering the impact of potential androgenetic alopecia and telogen effluvium.

      community You will lose hair if your prostaglandins aren't in balance

      in Research/Science  55 upvotes 8 months ago
      Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

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