Cicatricial Alopecia Secondary to Radiation Therapy: Case Report and Review of the Literature

February 2008 in “ PubMed ”

Gregg A Severs, Thomas D. Griffin, Maria Werner‐Wasik

cicatricial alopecia radiation therapy intracranial malignancies hair follicles alopecia histopathology clinical scarring dermal fibrosis hair transplantation

TLDR Keeping radiation doses under 16 Gy may reduce permanent hair loss.

The document discussed cicatricial alopecia resulting from high-dose radiation therapy (RT) used to treat intracranial malignancies, which can permanently destroy hair follicles and lead to permanent alopecia. A case was reported where radiation-induced cicatricial alopecia was confirmed by histopathology without obvious clinical scarring or dermal fibrosis, making the patient a good candidate for hair transplantation. The study suggested that if the radiation dose is kept under 16 Gy at a depth of 5 mm, the incidence of radiation-induced cicatricial alopecia could be avoided or significantly reduced.

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