Cutaneous Side-Effects of EGFR Inhibitors and Their Management

    January 2011 in “ PubMed ”
    Laura Maximiliane Ehmann, Thomas Ruzicka, Andreas Wollenberg
    TLDR EGFR inhibitors often cause skin issues like acne and dryness, which can be managed with specific treatments.
    Epidermal growth factor receptor (EGFR) inhibitors, used for treating metastasized cancer, frequently caused cutaneous side-effects due to EGFR's role in epidermis and hair follicle functions. Early in treatment, patients often experienced acneiform eruptions, while xerosis and fissures appeared later. Less common side-effects included paronychia and changes in hair growth, typically occurring after prolonged treatment. The document provided an overview of these side-effects and discussed potential therapeutic options for managing them.
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