Perifollicular Xanthomas Associated With Epidermal Growth Factor Receptor Inhibitor Therapy

January 2010 in “ Acta Dermato Venereologica ”

Tatiana Eames, Julia Kroth, Michael J. Flaig, Thomas Ruzicka, Andreas Wollenberg

perifollicular xanthomas epidermal growth factor receptor inhibitors cetuximab panitumumab EGFR acneiform skin reactions xerosis hair changes nail changes EGFR inhibitors skin reactions dry skin

TLDR EGFR inhibitors can cause yellowish skin eruptions.

The document reported a case of a 43-year-old woman who developed perifollicular xanthomas, characterized by a yellowish papular eruption, during a treatment change from cetuximab to panitumumab, both of which are epidermal growth factor receptor (EGFR) inhibitors. EGFR inhibitors are commonly used in the treatment of various solid tumors due to their role in cell proliferation, differentiation, and angiogenesis. However, these inhibitors often cause cutaneous side effects, including acneiform skin reactions, xerosis, and changes in hair and nails, due to EGFR expression in normal epidermis and associated structures.

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Perifollicular Xanthomas Associated With Epidermal Growth Factor Receptor Inhibitor Therapy

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