Acanthosis Nigricans, Insulin Resistance, and Cutaneous Virilism
January 1988
TLDR The conclusion is that there's a link between high testosterone levels, insulin resistance, and certain skin conditions, regardless of obesity.
In 1988, a study involving 13 patients found a correlation between acanthosis nigricans, insulin resistance, and cutaneous virilism, with the patients exhibiting dermatoses related to hyperandrogenism. The patients had higher fasting plasma insulin levels and increased insulin resistance, which correlated with total serum testosterone. The study concluded that there was a relationship between serum testosterone levels and insulin resistance, independent of obesity. The document also discussed various studies related to skin disorders, insulin resistance, and hormonal imbalances. Another study involving 103 children and adolescents with obesity found a significant association between insulin resistance and skin conditions like acanthosis nigricans, keratosis pilaris, and acne vulgaris. The document concluded that understanding these relationships could provide insights into the endocrinological and hormonal roles in these conditions.
