Lanostane-Type Triterpenes from the Sclerotium of Inonotus Obliquus (Chaga Mushrooms) as Proproliferative Agents on Human Follicle Dermal Papilla Cells

January 2019 in “ Journal of Natural Medicines ”

Kazumi Sagayama, Naonobu Tanaka, Takatoshi Fukumoto, Yoshiki Kashiwada

lanostane-type triterpenes Chaga mushrooms human follicle dermal papilla cells HFDPCs lanosterol inotodiol trametenolic acid minoxidil testosterone 5α-reductase androgen receptor alopecia hair growth cycle Chaga Rogaine testosterone 5-alpha-reductase hair loss hair growth

Studysummary This study found that certain compounds from Chaga mushrooms stimulated the proliferation of human hair follicle cells more effectively than minoxidil, suggesting potential for hair-growth treatments.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study examined the impact of lanostane-type triterpenes from Chaga mushrooms on human follicle dermal papilla cells (HFDPCs) to evaluate their hair growth-promoting potential. Five triterpenes were isolated, including lanosterol, inotodiol, and trametenolic acid, which showed stronger proproliferative effects on HFDPCs than minoxidil, a common hair growth treatment. These compounds did not inhibit testosterone 5α-reductase or the androgen receptor, suggesting they work differently from some existing alopecia treatments. Ongoing research was looking into how these triterpenes affect gene expression related to the hair growth cycle. The study was supported by JSPS KAKENHI and SVENSON Co., Ltd.

View this study on link.springer.com →

Discuss this study in the Community →

Research cited in this study

8 / 8 results

research Hair Growth Promoting Activity of Cedrol Isolated from the Leaves of Platycladus Orientalis

39 citations , July 2016 in “Biomedicine & Pharmacotherapy”

In this animal study, researchers found that cedrol, a constituent from Platycladus orientalis, significantly promoted hair growth in a dose-dependent manner in female C57BL/6 mice, surpassing results from blank control and 2% minoxidil groups over 21 days.

research The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases

218 citations , December 2011 in “Advances in Urology”

This review discusses the biochemical properties and clinical significance of 5 alpha-reductase isozymes and reports no new clinical results.

research Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men

198 citations , October 2011 in “Journal der Deutschen Dermatologischen Gesellschaft”

This article discusses the development of an evidence-based guideline for treating androgenetic alopecia and reports no new research results.

research Hair Growth Regulation by the Extract of Aromatic Plant Erica Multiflora

22 citations , March 2009 in “Journal of Natural Medicines”

This study found that Erica multiflora extract promotes hair growth by enhancing dermal papilla cell activity and shifting hair follicles from the telogen to the anagen phase in both in vitro and in vivo models.

research Stress And The Hair Follicle

61 citations , March 2003 in “American Journal Of Pathology”

Stress can cause hair loss and skin issues by affecting hair growth cycles.

research Treatments for Androgenetic Alopecia and Alopecia Areata

72 citations , January 2001 in “Drugs”

This review discusses current and emerging drug therapies for treating androgenetic alopecia and alopecia areata, and reports no clinical results; it highlights a need for improved and novel treatments.

research Stress, Hair Growth Control, and the Neuro-Endocrine-Immune Connection

7 citations , October 2000 in “Allergo Journal”

Stress may affect hair growth by influencing hair follicle development and could contribute to hair loss.

research Proanthocyanidins from Grape Seeds Promote Proliferation of Mouse Hair Follicle Cells In Vitro and Convert Hair Cycle In Vivo

64 citations , October 1998 in “Acta dermato-venereologica”

This study found that proanthocyanidins from grape seeds significantly promote hair follicle cell proliferation and hair cycle transition in mice, suggesting their potential as hair growth agents.