8 citations,
November 2017 in “Journal of Investigative Dermatology” AGA linked to inflammation, stress, fibrosis, and disturbed hair follicle stem cells.
80 citations,
May 2018 in “Trends in Molecular Medicine” Lichen Planopilaris and Frontal Fibrosing Alopecia may help us understand hair follicle stem cell disorders and suggest new treatments.
35 citations,
May 2021 in “Nature communications” The skin's basement membrane has specialized structures and molecules for different tissue interactions, important for hair growth and attachment.
4 citations,
September 2020 in “British Journal of Pharmacology” Activating TRPV4 in skin cells helps regrow hair in mice, possibly offering a treatment for hair loss.
37 citations,
May 2018 in “Frontiers in physiology” Certain RNA molecules are important for the development of wool follicles in sheep.
4 citations,
June 2021 in “Frontiers in Pharmacology” Bone marrow stem cells and their medium help hair regrowth.
20 citations,
May 2015 in “Regenerative Medicine” The document warns against US clinics selling untested stem cell treatments without FDA approval.
M-CSF-stimulated myeloid cells can turn into skin cells and help heal wounds and regrow hair.
69 citations,
August 1999 in “Developmental biology” The nude gene causes skin cell overgrowth and improper development, leading to hair and urinary issues.
September 2023 in “Nature Communications” Immune cells are essential for skin regeneration using biomaterial scaffolds.
1 citations,
January 2019 in “Springer eBooks” Hidradenitis Suppurativa is a chronic skin condition best treated early with surgery for better outcomes and less recurrence.
March 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” A specific immune response helps control mite populations on the skin, maintaining healthy hair follicles.
19 citations,
December 2018 in “Experimental and Molecular Medicine” Small molecule IM boosts hair growth by changing stem cell metabolism.
4 citations,
February 2022 in “Frontiers in molecular biosciences” Chronic stress in mice changes skin metabolism and gene expression, leading to hair loss.
10 citations,
October 2020 in “Frontiers in Cell and Developmental Biology” Wounds can regenerate hair in young mice, but this ability declines with age, offering insights for improving tissue regeneration in the elderly.
August 2024 in “Cell Death and Disease” Activating TLR9 helps heal wounds and regrow hair by using specific immune cells.
15 citations,
May 2021 in “British journal of dermatology/British journal of dermatology, Supplement” Cell therapy shows promise for treating severe psoriasis but needs more research to confirm safety and effectiveness.
November 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” MOF controls skin development by regulating genes for mitochondria and cilia.
6 citations,
November 2022 in “Development” New research shows that skin diversity is influenced by different types of dermal fibroblasts and their development, especially involving the Wnt/β-catenin pathway.
10 citations,
January 2018 in “Elsevier eBooks” Burn scars heal abnormally and more research is needed to find better treatments.
September 2023 in “Frontiers in bioengineering and biotechnology” JAGGED1 could help regenerate tissues for bone loss and heart damage if delivered correctly.
2 citations,
June 2022 in “Human Gene Therapy” Increasing miR-149 reduces hair follicle stem cell growth and hair development by affecting certain cell growth pathways.
65 citations,
December 2013 in “Acta Biomaterialia” The new matrix improves skin regeneration and graft performance.
13 citations,
December 2012 in “Cells” Targeting the actin cytoskeleton could improve skin healing and reduce scarring.
Delta-opioid receptors affect skin cell circadian rhythms, possibly impacting wound healing and cancer.
98 citations,
May 2008 in “British Journal of Dermatology” There are many treatments for permanent hair loss disorders, but their effectiveness varies and there's no clear best option.
28 citations,
September 2015 in “Wiener Klinische Wochenschrift” New skin substitutes for treating severe burns and chronic wounds are being developed, but a permanent solution for deep wounds is not yet available commercially.
5 citations,
January 2013 in “Cells Tissues Organs” Activin B helps start and grow hair follicles in mice.
The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.
77 citations,
July 2020 in “Journal of the European Academy of Dermatology and Venereology” Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.