Metabolic Regulation of Stem Cells in Aging

The document reviews the relationship between metabolism, dietary interventions, and stem cell function in the context of aging. It emphasizes that dietary restriction, including caloric and specific amino acid restriction, can positively affect stem cell function and longevity, particularly in intestinal, hematopoietic, skeletal muscle, and neural stem cells. Key metabolic pathways, such as mTOR and AMPK, are identified as important regulators of stem cell behavior, with the potential for dietary or therapeutic interventions to improve age-related decline in stem cell function. The review also notes that aging leads to a loss of self-renewal capacity in stem cells, an increase in HSC numbers, myeloid lineage skewing, and clonal hematopoiesis, driven by mutations and oxidative stress. It suggests that future research using single-cell -omic technologies will enhance our understanding of stem cell metabolism and lead to better strategies for tissue repair in aging. No human or animal subjects were involved in the research presented in the document.