Thymic Stromal Lymphopoietin Controls Hair Growth

The study identifies thymic stromal lymphopoietin (TSLP) as a key factor in promoting hair growth, particularly in response to skin injury. TSLP is produced during the anagen phase and after wounding, enhancing hair follicle cell proliferation and tissue regeneration. Experiments with mice showed that TSLP accelerates wound-induced hair growth (WIHG) by expanding CD34+ITGα6lo transit-amplifying cells and promoting keratinocyte proliferation. Blocking TSLP signaling delayed hair growth, while genetic deletion of TSLPR in hair follicle stem cells significantly hindered this process. These findings suggest TSLP's potential as a therapeutic target for hair loss conditions.