This study found that supercritical fluid extraction of germinated perilla seed significantly promoted hair follicle cell proliferation and gene expression related to hair growth, suggesting its potential as a natural treatment for hair loss.
This review highlights new treatment options for alopecia, including JAK inhibitors and Wnt pathway-targeting therapies, which may offer better efficacy and safety than traditional treatments like minoxidil and finasteride, but notes the need for more research on long-term effects and patient-specific responses.
December 2024 in “Cureus” This case study reports a young male with alopecia universalis experienced significant hair whitening following baricitinib treatment, highlighting the need for further research on JAK inhibitors' impact on hair pigmentation and their underlying mechanisms.
November 2024 in “European Journal of Pharmacology” In this study, MitoQ was found to enhance hair growth and reverse DHT-induced hair loss in a mouse model of androgenetic alopecia by mediating the WNT/β-catenin pathway and increasing CYP19A1 expression, suggesting potential as a therapeutic intervention.
August 2024 in “International Journal of Basic & Clinical Pharmacology” This literature review examined research on hair follicle biology and hair loss treatments, highlighting the potential of secretome-based therapies, which may enhance hair regeneration and address limitations of treatments like minoxidil and finasteride.
August 2024 in “International Journal of Molecular Sciences” This study found that root hairs of wild-type Arabidopsis grow faster and longer under low potassium stress, with changes in actin filament dynamics and specific regulation by the actin bundling proteins VLN1 and VLN4.
January 2024 in “Biological & clinical sciences research journal” This review of 355 articles found that apigenin, a compound found in many plants and vegetables, is mainly researched for its anti-inflammatory, neuroprotective, and anti-cancer properties, with enhanced efficacy when combined with allopathic drugs.
January 2024 in “Journal of applied biological chemistry” This study found that Glehnia littoralis and Andrographis paniculata may support hair growth by protecting against oxidative stress and increasing VEGF and Wnt/β-catenin signaling in human hair follicle dermal papilla cells, with enhanced effects when combined.
This study found that activating KATP channels with pinacidil may reduce antioxidant levels and mortality in honey bees, suggesting a role in regulating antiviral immunity through reactive oxygen species.
December 2016 in “Springer eBooks” This review examines the clinical features, causes, diagnosis, and treatment of Chrousos syndrome but reports no new experimental findings on this condition.
63 citations
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May 2011 in “Clinical cancer research” In this study, topical CUR61414 was effective in inhibiting basal cell carcinomas in mice, but no clinical activity was observed in human trials.
29 citations
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May 2018 in “Clinical Endocrinology” This review discusses the differential diagnosis of low-renin hypertension and highlights recent genetic discoveries related to familial forms, but it presents no new clinical results.
77 citations
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July 2012 in “Journal of Investigative Dermatology” The researchers observed that overexpression of Wnt10b in a mouse model can induce hair follicle regeneration by switching follicles from the resting phase to the growth phase via the Wnt-β-catenin signaling pathway.
51 citations
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September 2020 in “Cell Metabolism” This study highlights that the mammalian target of rapamycin complex 2 (mTORC2)-Akt signaling axis is essential for hair follicle stem cells to return to their niche and regenerate effectively by regulating metabolic pathways.
14 citations
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May 2020 in “Biomolecules & Therapeutics” This study found that vanillic acid from wheat bran promoted dermal papilla cell proliferation, potentially stimulating hair growth by activating the PI3K/Akt and Wnt/β-catenin pathways.
December 2025 in “Nature Communications” This study demonstrated that skin organoids derived from human stem cells can model cutaneous tuberculosis, revealing that fibrosis development in Mycobacterium tuberculosis-infected organoids is linked to the PI3K-AKT and AP1 pathways in fibroblasts, and suggesting the potential for antifibrotic treatment evaluation.
December 2024 in “Frontiers in Pharmacology” In this study, human cell models of hair follicles showed that araliadiol, a plant-derived polyacetylene compound, promotes hair growth through the p38/PPAR-γ signaling pathway, suggesting its potential as a new drug candidate for alopecia treatment.
March 2024 in “Nutrients” This study found that Gynostemma pentaphyllum leaf hydrodistillate (GPHD) promoted hair growth in mice similarly to minoxidil and upregulated growth factor expression via the AKT/β-catenin signaling pathway, with damulin B identified as an active component contributing to these effects.
September 2022 in “Institutional Repositories DataBase (IRDB)” 3D-oxy exosomes may significantly boost hair growth, offering new treatment options for hair loss.
January 2016 in “Research Explorer (The University of Manchester)” Activating the Eda/Edar pathway improves wound healing by enhancing hair follicle growth.
19 citations
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October 2017 in “European Journal of Pharmaceutics and Biopharmaceutics” This study found that the MXD/HP-β-CD GEL formulation promoted greater hair growth and improved gene expression related to hair growth in male rats compared to MXD solution or control groups.
6 citations
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June 2011 in “British Journal of Dermatology” This study found that individuals with alopecia areata had significantly higher serum levels of retinol-binding protein 4 and increased IgG immunoreactivity against it, suggesting a role in the disease's pathogenesis.
November 2024 in “Open Repository of the University of Porto (University of Porto)” This report details a six-month internship experience, split between hospital and community pharmacy settings, which enhanced practical skills and theoretical knowledge in pharmaceutical care and highlighted the pharmacist's role in ensuring safe medication use.
1 citations
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May 2022 in “Frontiers in Pharmacology” This study found that astilbin downregulates effector CD4+ T cell activities through the CYP1B1/ROS/PPARγ pathway, suggesting its potential use in treating inflammation.
January 2026 in “Applied Sciences” In this study, cyclic ADP-ribose (cADPR) treatment in human hair follicle dermal papilla cells was associated with increased intracellular calcium retention and activated anagen-related signaling without causing significant cytotoxicity, indicating its potential impact on hair growth processes.
42 citations
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July 2017 in “Molecular therapy” This study found that applying a tocotrienol-rich phytochemical topically induced hair follicle development in adult mice, revealing a new epidermal pathway involving E-cadherin and β-catenin.
April 2026 in “Antioxidants” In this study, broccoli sprout extract and sulforaphane were found to reduce cell viability, suppress growth, and induce apoptosis in breast cancer cells, and oral broccoli sprout extract inhibited tumor growth in animal models, suggesting it may be effective in managing breast cancer.
January 2020 in “Korean journal of ophthalmology/Korean Journal of Ophthalmology” This study found that minoxidil increases trabecular meshwork cell permeability, possibly via the downregulation of tight junction proteins and the generation of reactive oxygen species.
August 2024 in “Plant Signaling & Behavior” This study found that overexpressing the gene OsPRX83 in rice plants enhanced osmotic and oxidative stress tolerance compared to wild-type and mutant rice, showing potential for engineering drought-resistant rice varieties through ABA-dependent pathways and ROS scavenging.
15 citations
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November 2020 in “International Journal of Molecular Sciences” This study found that multi-walled carbon nanotubes promoted root hair growth in certain plants, with results indicating they modulate nitric oxide and ethylene pathways crucial to this development.