TLDR Minoxidil increases cell layer permeability by reducing tight junction proteins and raising ROS levels.
The study demonstrated that minoxidil sulfate (MS) increased trabecular meshwork (TM) permeability primarily through the paracellular pathway by downregulating tight junction proteins occludin and claudin-5. MS exposure did not affect caveolin-1 levels, indicating no significant impact on the transcellular pathway. Additionally, MS increased reactive oxygen species (ROS) generation, and the permeability increase was attenuated by the antioxidant N-acetyl cysteine (NAC), suggesting ROS involvement in the process. The findings highlighted the need for further in vivo studies to fully understand the mechanisms and potential therapeutic implications.
74 citations,
May 2004 in “Journal of Clinical Hypertension” Minoxidil effectively treats severe hypertension, but watch for side effects.
August 2023 in “Journal of Cosmetic Dermatology” Some plants like spinach, broccoli, and matcha may boost the effectiveness of the hair growth drug minoxidil.
8 citations,
April 2019 in “Dermatologic Therapy” Tretinoin boosts minoxidil's effect on hair loss by increasing enzyme activity.
5 citations,
January 2018 in “Italian journal of dermatology and venereology” Minoxidil effectively stimulates hair growth in androgenetic alopecia.
1 citations,
January 2010 Mesotherapy is more effective than topical spray for female hair loss treatment.
269 citations,
August 2002 in “Journal of The American Academy of Dermatology” 5% minoxidil works better for hair growth and density, with minor irritation.
39 citations,
March 1987 in “Journal of The American Academy of Dermatology” Topical minoxidil is a safe and effective treatment for hair loss caused by androgenetic alopecia.
20 citations,
February 1985 in “Archives of Dermatology” Minoxidil helps hair regrowth, especially with more indeterminate hairs.
