Unexpected Extensive Hair Whitening Following Baricitinib Treatment for Alopecia Universalis: A Case Report and Mechanistic Insights

    December 2024 in “ Cureus ”
    Abhesh Lawati Limbu, Jun Xie, Ji Quan Song
    Studysummary This case study reports a young male with alopecia universalis experienced significant hair whitening following baricitinib treatment, highlighting the need for further research on JAK inhibitors' impact on hair pigmentation and their underlying mechanisms.
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    Research cited in this study 15

    1. Two Case Studies of Persistent White Hair Regrowth After Alopecia Areata Turning Pigmented Following Treatment Journal of Cosmetic Dermatology · 2024
    2. Baricitinib for the Treatment of Alopecia Areata Drugs · 2023
    3. Case Report: Successful Treatment of Alopecia Universalis With Tofacitinib and Increased Cytokine Levels: Normal Therapeutic Reaction or Danger Signal? Frontiers in Immunology · 2022
    4. The JAK/STAT Signaling Pathway: From Bench to Clinic Signal Transduction and Targeted Therapy · 2021
    5. The Effect of JAK Inhibitor on Survival, Anagen Re-Entry, and Hair Follicle Immune Privilege Restoration in Human Dermal Papilla Cells International Journal of Molecular Sciences · 2020
    6. Hyperactivation of Sympathetic Nerves Drives Depletion of Melanocyte Stem Cells Nature · 2020
    7. Alopecia Areata Profiling Shows TH1, TH2, and IL-23 Cytokine Activation Without Parallel TH17/TH22 Skewing ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology · 2015
    8. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    9. Patchy Alopecia Areata Sparing Gray Hairs: A Case Series Postępy Dermatologii i Alergologii · 2014
    10. Sudden Whitening of the Hair in an 82-Year-Old Woman: The 'Overnight Greying' Phenomenon Clinical and Experimental Dermatology · 2012
    11. The Cell Biology of Human Hair Follicle Pigmentation Pigment cell & melanoma research · 2010
    12. Marie Antoinette Syndrome Archives of Dermatology · 2009
    13. A Case of Patchy Alopecia Areata Sparing Lesional Greying Hairs International Journal of Dermatology · 2008
    14. A Case of Widespread Non-Pigmented Hair Regrowth in Diffuse Alopecia Areata Australasian Journal of Dermatology · 2007
    15. Persistent Depigmented Regrowth After Alopecia Areata Journal of the American Academy of Dermatology · 2002

    Related research 6

    1. Myeloproliferative Disorder Associated With Alopecia Universalis JAAD Case Reports · 2024
    2. Case Report of Novel Combination of Anthralin and Calcipotriene Leading to Trichologic Response in Alopecia Areata JAAD case reports · 2019
    3. Alopecia Areata: A Multifactorial Autoimmune Condition Journal of autoimmunity · 2018
    4. Treating Resistant Cases of Alopecia Universalis Journal of cosmetology & trichology · 2018
    5. Treatment of Alopecia Universalis with Oral Alitretinoin: A Case Report JAAD case reports · 2017
    6. Efficacy of Tofacitinib in Treatment of Alopecia Universalis in Two Patients Journal of the European Academy of Dermatology and Venereology · 2016