Diagnostic Approach to Low-Renin Hypertension

    May 2018 in “ Clinical Endocrinology ”
    Silvia Monticone, Isabel Losano, Martina Tetti, Fabrizio Buffolo, Franco Veglio, Paolo Mulatero
    Image of study
    TLDR Recent genetic insights show that low-renin hypertension includes a range from essential hypertension to secondary or familial forms, affecting diagnosis and treatment.
    The document from June 6, 2018, reviews the diagnostic approach to low-renin hypertension (LRH), which is present in about 30% of hypertensive patients. It emphasizes the importance of differential diagnosis based on family history, serum aldosterone, and plasma potassium levels, as each form of LRH requires specific targeted therapy. The paper discusses various conditions associated with LRH, including an autosomal dominant condition with a mutation in the NR3C2 gene, Pseudohypoaldosteronism type 2 (Gordon's syndrome), and low renin essential hypertension (LREH). It also explores the role of single nucleotide polymorphisms (SNPs) in LREH. The conclusion is that recent genetic insights have altered the classical view of LRH, indicating a spectrum between low renin essential hypertension and secondary or familial forms such as primary aldosteronism, Liddle syndrome, and AME syndrome, which has important diagnostic and therapeutic consequences.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 1000+ results

      community Being Safe on Oral Minoxidil: tl;dr on the literature.

      in Research/Science  47 upvotes 2 weeks ago
      Oral minoxidil is effective for hair loss but can cause cardiovascular side effects, such as pericardial effusion, especially in those with genetic predispositions. Starting with low doses and monitoring cardiovascular health are advised to reduce risks.
      [object Object]

      community Nothing's working, I feel depressed, also hopeless for the first time

      in Update  104 upvotes 2 years ago
      A user's experience with hair loss treatments, including Finasteride, Minoxidil, Nizoral Shampoo, Rosemary Oil, Vitamin D, Biotin, Vitamin C, Zinc and Dermarolling, that have not been successful over the past 14 months. Other users gave advice on how to cope with the issue, such as exercising, changing mindset, and shaving their head.

      community What's "wrong" with oral minoxidil, exactly?

      in Minoxidil  173 upvotes 3 months ago
      Oral minoxidil can boost hair growth but may cause side effects like heart palpitations and increased body hair. Many prefer topical minoxidil due to fewer side effects.

      community Using Antihypertensive drugs for hair loss

      in Chat  6 upvotes 2 years ago
      The conversation discusses the potential connection between baldness, heart disease, and high blood pressure. Treatments mentioned include Minoxidil, Spironolactone, and Finasteride.

      community Low-Dose Oral Minoxidil Does Not Significantly Affect BP

      in Minoxidil  178 upvotes 2 months ago
      Low-dose oral minoxidil is used for hair loss and does not significantly affect blood pressure but may increase heart rate and cause hypotensive symptoms. Some users experience side effects like palpitations and shortness of breath, while others find it effective; topical minoxidil with tretinoin is also considered.

    Similar Research

    5 / 1000+ results