May 2019 in “Clinica chimica acta” This study reported that mice with more diverse gut microbiota showed higher hair levels of certain hormones and 1-AG compared to those with less diverse microbiota, though plasma differences were more complex and varied by stress and sex.
November 2022 in “Journal of the Endocrine Society” This case report suggests that genetic evaluation for glucocorticoid resistance, such as the NR3C1 gene variant, is crucial for proper diagnosis and management of patients showing atypical signs of hypercortisolism.
October 2013 in “Journal of the American College of Cardiology” This study found that individuals with a nondipper blood pressure pattern had significantly higher 24-hour urinary aldosterone levels than those with a dipper pattern.
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November 1999 in “Fertility and Sterility” This study found that a basal 17-hydroxyprogesterone level is effective for screening nonclassic adrenal hyperplasia in women, with a 4 ng/mL cutoff providing high specificity and positive predictive value.
In this study, a 37-year-old female with resistant hypertension and signs of Cushing's syndrome and primary aldosteronism was found to have normal cortisol levels but high levels of cortisol and aldosterone via adrenal venous sampling, leading to a diagnosis confirmed by right adrenalectomy.
