Human Pluripotent Stem Cell-Derived Skin Organoids Enabled Pathophysiological Model of Mycobacterium Tuberculosis Infection

    December 2025 in “ Nature Communications ”
    Yue Liang, Yating Liang, Pengfei Zhong … Ying‐Xia Tan
    Studysummary This study demonstrated that skin organoids derived from human stem cells can model cutaneous tuberculosis, revealing that fibrosis development in Mycobacterium tuberculosis-infected organoids is linked to the PI3K-AKT and AP1 pathways in fibroblasts, and suggesting the potential for antifibrotic treatment evaluation.
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    Research cited in this study 7

    1. A Skin Organoid-Based Infection Platform Identifies an Inhibitor Specific for Hand, Foot, and Mouth Disease Nature Communications · 2025
    2. Applications of Human Pluripotent Stem Cell-Derived Skin Organoids in Dermatology ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2023
    3. Characterization of the Epidermal-Dermal Junction in hiPSC-Derived Skin Organoids Stem cell reports · 2022
    4. Generation And Characterization Of Hair-Bearing Skin Organoids From Human Pluripotent Stem Cells Nature Protocols · 2022
    5. Generation of Skin Organoids: Potential Opportunities and Challenges Frontiers in cell and developmental biology · 2021
    6. Skin Organoids: A New Human Model for Developmental and Translational Research Experimental Dermatology · 2021
    7. Hair-Bearing Human Skin Generated Entirely From Pluripotent Stem Cells Nature · 2020