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research Targeting a fibrotic bottleneck may provide an opening in the treatment of LUTS

2 citations , March 2019 in “American journal of physiology. Renal physiology./American journal of physiology. Renal physiology”

This paper discusses the potential of targeting fibrosis in addressing lower urinary tract symptoms associated with benign prostatic hyperplasia, but it provides no new clinical findings and highlights the need for further research.

research Surgical Treatment Combined With Concentrated Growth Factor Injection for a Case of Pseudopelade of Brocq

March 2025 in “Journal of Cosmetic Dermatology”

In this case study, a 29-year-old woman with Pseudopelade of Brocq, a type of scarring alopecia, showed significant hair density improvement following a combination of scalp reduction surgery and concentrated growth factor injections postoperatively, which addressed scar complications and inflammation.

Perifollicular Inflammation and Fibrosis in Androgenetic Alopecia: Implications for Diagnosis and Treatment - A Comparative Histopathologic and Clinical Study with Normal-Appearing Scalp

research Perifollicular Inflammation and Fibrosis in Androgenetic Alopecia: Implications for Diagnosis and Treatment - A Comparative Histopathologic and Clinical Study with Normal-Appearing Scalp

January 2026 in “Clinical Cosmetic and Investigational Dermatology”

This study found that targeting both hormonal and immune pathways improved treatment outcomes in androgenetic alopecia patients with an under-recognized inflammatory component called PIILIF, which may contribute to treatment resistance.

research Treatment of central centrifugal cicatricial alopecia with topical metformin 10% cream: case report and literature review

June 2024 in “International Journal of Dermatology”

In this article, a case report examines the use of topical metformin 10% cream for treating central centrifugal cicatricial alopecia, contributing to existing literature on potential treatments for this condition.

research Topical Spironolactone in the Treatment of Evaporative Dry Eye Disease

1 citations , June 2023 in “Cureus”

In a retrospective study, researchers found that topical spironolactone improved tear film quality and reduced inflammation related to meibomian gland dysfunction and evaporative dry eye in patients, demonstrating good tolerability and suggesting it as a potential therapy for managing the condition.

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5 / 9 results

community Anti-oxidants that reverse hairloss?

86 upvotes 5 years ago

Resveratrol and fisetin, found in red wine and strawberries, may promote hair growth by affecting hair follicle cells. Users discuss various treatments, including natural remedies like saw palmetto and topical applications, with mixed opinions on their effectiveness compared to pharmaceuticals like finasteride.

community Topical caffeine as an adjunct treatment. I think this should be considered.

4 upvotes 3 years ago

Topical caffeine is suggested as a beneficial adjunct treatment for hair growth due to its anti-fibrotic, anti-inflammatory, antioxidant, and other properties. There is skepticism about its effectiveness, especially at low concentrations like in Alpecin liquid.

community Reducing Fibrosis in Hair Loss: Topical Pirfenidone

59 upvotes 5 months ago

Topical pirfenidone is highlighted as an effective anti-inflammatory and anti-fibrotic treatment for hair loss, particularly in addressing perifollicular fibrosis, which may enhance the effectiveness of standard treatments like finasteride and minoxidil. The user also uses calcipotriol, MCT oil, ciclopirox shampoo, and benzoyl peroxide shampoo as part of their regimen.

community What is the ultimate hair regrowth protocol

29 upvotes 1 year ago

The conversation covers aggressive hair regrowth treatments like Dutasteride, Minoxidil (oral and topical), RU58841, microneedling, and ketoconazole shampoo. It also mentions PRP, laser therapy, GHK-Cu injections, and hormone therapy for maximum regrowth.

community Holding out for a miracle drug

59 upvotes 4 months ago

A 41-year-old male has been using a combination of treatments for hair regrowth, including finasteride, minoxidil, a laser cap, ketoconazole shampoo, and rosemary oil, with some progress noted. He is maintaining his current regimen in hopes of a future miracle drug while considering hair transplants and other treatments like dutasteride and copper peptides.

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