May 2026 in “International Journal of Molecular Sciences” In this study, a new formulation of human placental extract showed antioxidant and neurite outgrowth activities, significantly reduced hair graying in mice, and alleviated neuropathy symptoms, suggesting potential therapeutic benefits.
24 citations
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January 2015 in “Annals of Dermatology” In this study, herbal extracts commonly used in traditional medicine were observed to significantly increase the proliferation of human dermal papilla cells, suggesting potential as alternative therapies for enhancing hair growth.
April 2018 in “Journal of Investigative Dermatology” This study found that the PPAR-γ modulator AGED can reverse epithelial-mesenchymal transition in hair follicles affected by lichen planopilaris ex vivo, suggesting potential for treating scarring alopecias.
3 citations
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December 2015 in “Asian journal of dermatology” This study reports that applying Natural Plant Extracts containing sweet flag significantly reduced hair loss and increased hair density and thickness in people with alopecia over 10 months.
1 citations
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October 2001 in “Journal of Wood Science” This study found that extracts from the fungus YL161, Agaricus blazei, and the bark of Camptotheca cuminata promoted dermal papilla cell growth more effectively than pentadecanoic acid, suggesting potential for stimulating hair growth.
1 citations
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September 2022 in “Evidence-based Complementary and Alternative Medicine” In this study, Gardenia florida fruit extract promoted hair growth in vitro and in vivo by enhancing hair growth-promoting gene expression and increasing hair follicle number, size, and depth in mice.
4 citations
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June 2011 in “Journal of Biomedical Research” This study suggests that a herbal extract from Gardenia, Mentha arvensis, Rosemary, and Lavender may promote hair growth in mice at a rate comparable to minoxidil.
January 2018 in “The Korea Journal of Herbology” This study found that water extract of Puerariae Radix may promote hair growth by increasing the mRNA expression levels of hair growth-related genes in human dermal papilla cells, unlike the juice extract.
21 citations
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January 2020 in “Pharmaceutical Biology” In this study, Salvia plebeia extract promoted hair growth by enhancing proliferation and anti-apoptotic effects in human dermal papilla cells and increased hair growth in treated mice.
This study found that Ganoderma Lucidum extract and its active component, Ganoderic acid A, improved hair cell proliferation and growth factor expression in lab and clinical settings, demonstrating significant hair loss inhibition effects when used in shampoo and tonic formulations over 24 weeks.
1 citations
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January 2023 in “Bioscience Journal” This study found that combining sorafenib with Platycladus orientalis leaf extract effectively suppressed cervical cancer cell growth by increasing tumor suppressor gene expression and reducing anti-apoptotic gene expression, suggesting a potential rationale for further clinical trials.
January 2026 in “Frontiers in Medicine” In this study, PP-PTKL exhibited antioxidant, anti-inflammatory, and pro-melanogenic effects in laboratory settings, suggesting its potential role in preventing or treating hair greying. Further animal and human studies are needed to verify these findings.
January 2019 in “Prosiding Program Kreativitas Mahasiswa” This study found that a 15% Pisum sativum extract concentration in hair tonic showed the most effective hair growth, with a length of 14.51mm and weight of 0.16g.
70 citations
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May 2023 in “Molecules” This source reviews recent research on Ginkgo biloba, highlighting its medicinal benefits due to compounds in the leaves and concerns over toxic alkylphenols in seeds. It also discusses patents for its food production uses and ongoing studies on toxicity and drug interactions.
July 2022 in “Forte Journal” In this study, researchers tested hair tonic formulations with varying concentrations of bitter melon extract and found that higher concentrations enhanced hair growth in rabbits, with the 15% extract showing the greatest effect without causing skin irritation.
July 2026 in “International Journal of Molecular Sciences” This study found that TSG-enriched Polygonum multiflorum extract, optimized through microwave-assisted and chromatographic methods, promotes hair regrowth in a mouse model of androgenetic alopecia via 5α-reductase inhibition and Wnt/β-catenin pathway activation, suggesting its potential as a natural treatment.
April 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” In this study, Platycladus orientalis leaf extract loaded into hyaluronic acid microneedles was found to promote hair follicle growth by enhancing the environment for hair cell proliferation and activating repair pathways, suggesting potential as a treatment for androgenic alopecia.
18 citations
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January 2022 in “TURKISH JOURNAL OF AGRICULTURE AND FORESTRY” This study examined the extracts and essential oil from Platycladus orientalis leaves and found that the ethanol extract had the highest antioxidant activity, while the essential oil was more effective as an antibacterial agent, particularly against Micrococcus luteus and Staphylococcus aureus.
January 2010 in “대한미용학회지” This study found that extracts from Angelica gigas Nakai and Glycyrrhiza uralensis stimulated hair regrowth and follicle development in a shaving mouse model, suggesting potential for hair growth or hair loss prevention in humans.
4 citations
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March 2020 in “Journal of Cosmetic Dermatology” This study found that Plumbago zeylanica extract and its component plumbagin may help prevent androgenetic alopecia by promoting dermal papilla cell growth and reducing SRD5A2 expression.
April 2011 in “Cancer Research” In this study, ginsenoside 20(S)-protopanaxadiol-aglycone (PPD) was shown to downregulate androgen receptor expression and inhibit tumor growth in prostate cancer cells.
July 2023 in “Belarusian State Pedagogical University repository (Belarusian State Pedagogical University)” This study found that litchi twig water and ethanol extracts exhibited protective effects against DHT-induced damage in androgenetic alopecia models, suggesting potential for use in hair growth promotion and waste reduction.
4 citations
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June 2022 in “Frontiers in Cell and Developmental Biology” Plant extracts might help control stem cell growth for medical use.
March 2024 in “Journal of Pharmaceutical and Sciences” This study investigated the phytochemical composition and antibacterial and antioxidant activities of Zaleya pentandra extracts, finding high total polyphenol and flavonoid content and significant antibacterial effects, particularly in acetone extract, which may be suitable for developing antibacterial agents.
9 citations
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May 2015 in “Media Penelitian dan Pengembangan Kesehatan” This study found that a gel containing apigenin and celery juice improved hair growth in male Spraque-Dawley mice without causing significant skin irritation.
April 2023 in “Journal of Investigative Dermatology” This report details the development of a PSR™ Terminalia extract with antioxidant and anti-aging potential, highlighting its rich composition in phenolic acids, polysaccharides, and organic acids, without new clinical results.
March 2026 in “International Journal of Molecular Sciences” This study found that Grateloupia angusta extract improved wound healing by promoting matrix production and pro-angiogenic activity in cell cultures and enhanced early wound repair in a mouse skin incision model.
December 2015 in “아시안뷰티화장품학술지” This review discusses the various biological activities of Epigallocatechin Gallate (EGCG) and its potential uses in cosmetics, food, and medicine, without reporting new clinical findings.
5 citations
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February 2020 in “Open Access Macedonian Journal of Medical Sciences” In this study, ethanol extracts of Hibiscus rosa-sinensis leaves were found to promote hair growth in mice, with 10% concentration shown to be most effective over a 25-day observation period.
July 2024 in “Frontiers in Pharmacology” This study suggests that pilose antler extracts promote hair regrowth in androgenetic alopecia mice by activating the AKT and Wnt pathways, enhancing hair follicle stem cell proliferation.