In Vitro and In Silico Evaluation of Toxicological and Anti-Proliferative Activity in Phytochemical Compounds of Several Solvent Extracts from Zaleya Pentandra L
March 2024
in “
Journal of Pharmaceutical and Sciences
”
phytochemical compounds antioxidant antibacterial activities Zaleya pentandra ethanol extract hexane extract acetone extract ethyl acetate extract methanol extract HPLC-MS polyphenol content B. subtilis drug-likeness toxicological assessment pharmacokinetic assessment high-performance liquid chromatography-mass spectrometry Bacillus subtilis
TLDR Zaleya pentandra extracts, especially acetone, may be useful for new medicines and food industry applications.
The study investigates the phytochemical compounds, antioxidant, and antibacterial activities of five Zaleya pentandra extracts (ethanol, hexane, acetone, ethyl acetate, and methanol) using HPLC-MS. The acetone extract showed the highest total polyphenol content (323.06±1.74 mg GAE/g) and significant antibacterial activity against B. subtilis. Computational analysis indicated significant drug-likeness features, including toxicological and pharmacokinetic assessments. The findings suggest that Zaleya pentandra extracts, particularly the acetone extract, have potential applications in developing new therapeutic agents and in the food industry.
