In Vitro and In Silico Evaluation of Toxicological and Anti-Proliferative Activity in Phytochemical Compounds of Several Solvent Extracts from Zaleya Pentandra L
March 2024
in “
Journal of Pharmaceutical and Sciences
”
phytochemical compounds antioxidant antibacterial activities Zaleya pentandra ethanol extract hexane extract acetone extract ethyl acetate extract methanol extract HPLC-MS polyphenol content B. subtilis drug-likeness toxicological assessment pharmacokinetic assessment high-performance liquid chromatography-mass spectrometry Bacillus subtilis
Studysummary This study investigated the phytochemical composition and antibacterial and antioxidant activities of Zaleya pentandra extracts, finding high total polyphenol and flavonoid content and significant antibacterial effects, particularly in acetone extract, which may be suitable for developing antibacterial agents. Our plain-language summary of this paper — not a Tressless recommendation.
The study investigates the phytochemical compounds, antioxidant, and antibacterial activities of five Zaleya pentandra extracts (ethanol, hexane, acetone, ethyl acetate, and methanol) using HPLC-MS. The acetone extract showed the highest total polyphenol content (323.06±1.74 mg GAE/g) and significant antibacterial activity against B. subtilis. Computational analysis indicated significant drug-likeness features, including toxicological and pharmacokinetic assessments. The findings suggest that Zaleya pentandra extracts, particularly the acetone extract, have potential applications in developing new therapeutic agents and in the food industry.
