October 2025 in “Jurnal Ilmiah Kedokteran dan Kesehatan” This literature review reports that multivitamin supplementation can enhance hair density and quality in people with suboptimal nutritional status but warns that excessive intake of certain vitamins and minerals may cause hair loss.
This systematic review suggests that platelet-rich plasma may improve hair density, follicle survival, and hair growth when used with hair transplantation, though varied methods and lack of standardized evaluation limit the findings.
October 2025 in “Dermatologica Sinica” This study's network meta-analysis reported that botulinum injection combined with red laser and topical minoxidil is most effective for increasing hair density in androgenetic alopecia when using low-level laser therapy.
September 2025 in “Australian Journal of Herbal and Naturopathic Medicine” This review reported that Withania somnifera (Ashwagandha) significantly improved symptoms like vasomotor disturbances, psychological well-being, and sleep quality in perimenopausal women and was well tolerated, with largely mild side effects in examined trials.
August 2025 in “Journal of Cosmetic Dermatology” This review explores low-level light therapy's potential as a noninvasive treatment for various forms of alopecia, noting its promising results in hair regrowth and density but highlighting the need for standardized protocols and further research.
In this study, microneedling radiofrequency followed by topical exosome application was associated with significant increases in hair density and diameter, showing promising potential as a therapy for pattern hair loss.
July 2025 in “Frontiers in Medicine” In this systematic review and meta-analysis, the authors examined single-spin versus double-spin centrifugation protocols for PRP in patients with androgenic alopecia and found no significant difference in platelet concentration, hair density, or hair types between the protocols.
In this clinical trial, rosemary-lavender and rosemary-castor oils were found to significantly improve hair growth rate, thickness, density, length, and reduce hair fall compared to coconut oil over 90 days, indicating they may be effective natural alternatives for hair regrowth.
The researchers reported that a combined oral minoxidil-finasteride regimen significantly improved hair density in men with androgenetic alopecia over 12 months, although further confirmation in different trials is suggested.
June 2024 in “Journal of clinical oncology” This study found that sensor-controlled scalp cooling prevented visible hair loss in 53% of breast cancer patients undergoing chemotherapy, with greater hair density and absence of comorbidities enhancing its efficacy, also improving patients' quality of life without increasing scalp metastasis risk.
April 2024 in “Journal of applied cosmetology” This review reported on botulinum toxin's potential in treating dermatological conditions like hidradenitis suppurativa, rosacea, androgenetic alopecia, plaque psoriasis, and primary hyperhidrosis, highlighting initial efficacy but indicating a need for controlled trials to confirm safety and effectiveness.
January 2024 in “Advances in Cosmetic Surgery” This review highlights that robotic hair transplantation reliably and efficiently extracts follicular units with transection rates comparable to manual methods, potentially allowing more physicians to offer hair restoration without needing additional staff, and notes ongoing software advancements that could enhance aesthetic results.
January 2024 in “Dermatologic Therapy” This study reported that in patients with androgenic alopecia, platelet-rich plasma therapy's effectiveness in enhancing hair density and caliber was positively correlated with specific growth factor concentrations, notably glial cell-derived neurotrophic factor and platelet-derived growth factor-BB, while no significant correlations were found with demographic factors.
November 2023 in “International Journal of Pharmaceutics” This study found that a new transdermal drug delivery system using globefish skin collagen peptides and dissolving microneedles effectively promoted hair regrowth in mice with androgenetic alopecia by reducing inflammation and enhancing vascularization.
November 2023 in “Journal of Cosmetic Dermatology” This study highlights the potential of fat injections for treating alopecia, as they may promote hair regrowth, reduce inflammation, and exhibit limited adverse effects, suggesting efficacy and safety in managing the condition.
August 2023 in “Skin Research and Technology” This study found that platelet-rich plasma is effective and safe for treating chronic wounds, particularly diabetic and venous ulcers, and vitiligo, without increasing the risk of infection.
July 2023 in “Journal of Cutaneous and Aesthetic Surgery” This review suggests that combining PRP with minoxidil may be more effective for promoting hair growth in androgenetic alopecia than using either treatment alone, although study variations limit definitive conclusions.
42 citations
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May 2007 in “Endocrinology and metabolism/American journal of physiology: endocrinology and metabolism” In this animal study, administering testosterone alongside a 5α-reductase inhibitor counteracted testosterone's effects on prostate enlargement while preserving its beneficial effects on muscle and bone.
21 citations
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August 2020 in “Stem Cell Research & Therapy” This meta-analysis suggests that stem cell therapy may reduce burn wound area and improve healing-related factors in preclinical models, indicating potential for future clinical studies on burn treatment.
5 citations
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October 2023 in “International Wound Journal” In this study, a novel portable LED device significantly accelerated wound healing in rats, with faster wound closure, increased collagen deposition, and more microvessels at a higher radiation intensity, suggesting its potential for innovative wound management.
1 citations
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September 2023 in “Journal of cosmetic dermatology” This study suggests that Silybum marianum flower extract may promote hair growth and reduce hair loss by increasing proliferation and VEGF production in dermal papilla cells and suppressing cell senescence.
March 2025 in “Journal of Cosmetic Dermatology” This study explored the effects of TTFE on male androgenic alopecia, finding that topical application increased hair density, follicular diameter, and scalp hydration while reducing water loss and sebum production in a 12-week trial.
February 2025 in “Cureus” This study focused on developing and validating standardized methods to reliably assess hair growth and scalp health in androgenetic alopecia, finding significant differences in hair parameters such as vellus and terminal hair counts, density, and thickness between affected and standardized areas.
30 citations
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October 2013 in “BMC dermatology” In this animal study, topical VEGF gel increased hair growth and thickness in Mesocricetus auratus, although it was not completely inert, highlighting the need for further toxicity confirmation.
21 citations
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April 2019 in “Journal of cosmetic and laser therapy” This review examines the devices, mechanisms, risks, side effects, and regulatory differences in laser hair removal, particularly highlighting the lack of regulation in South Africa and its implications for patient safety.
12 citations
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February 2023 in “Stem Cell Research & Therapy” This study found that injecting hepatocyte growth factor-enhanced hair follicle stem cells into a rat model of ischemic stroke improved recovery by reducing inflammation, protecting the blood-brain barrier, and promoting angiogenesis.
9 citations
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February 2024 in “Indian Dermatology Online Journal” This study discusses the potential of advanced imaging technologies in dermatology to improve diagnostic accuracy and reduce the need for invasive procedures like biopsies, while noting significant barriers in adoption and accessibility in India due to costs and infrastructure constraints.
4 citations
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February 2025 in “Nutrients” This randomized controlled trial found that consuming *Gynostemma pentaphyllum* extract significantly improved hair elasticity, density, and diameter over 24 weeks without severe adverse events, suggesting it as a safe functional food ingredient for hair health improvement.
4 citations
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April 2022 in “Dermatologic Therapy” This study found that using autologous micrografts from scalp tissues significantly improved hair thickness and density in patients experiencing telogen effluvium following COVID-19, with notable improvements observed over a 6-month follow-up period.
4 citations
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December 2021 in “Applied sciences” This study observed that a combination of micro-needling and low-level light/laser therapy significantly increased hair density in patients with mild to moderate androgenic alopecia, showing an increase of 12 hairs/cm² after 16 weeks, compared to baseline.