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    Glossary Notch1

    gene crucial for cell communication and hair follicle regulation

    Notch1 is a gene that plays a crucial role in cell communication, influencing cell fate decisions, growth, and differentiation. In the context of hair biology, Notch1 signaling is important for the regulation of hair follicle development and cycling, which can impact conditions like alopecia.

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    1. Epidermal Notch signalling: differentiation, cancer and adhesion Current opinion in cell biology · 2008 · 253 citations
    2. The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling Development · 2011 · 134 citations
    3. Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately Stem Cell Research & Therapy · 2015 · 113 citations
    4. Impaired Notch‐MKP‐1 signalling in hidradenitis suppurativa: an approach to pathogenesis by evidence from translational biology Experimental dermatology · 2013 · 112 citations
    5. Activation of the Notch pathway in the hair cortex leads to aberrant differentiation of the adjacent hair-shaft layers Development · 2000 · 109 citations
    6. Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair Nature Communications · 2016 · 86 citations
    7. Dynamic regulation of retinoic acid-binding proteins in developing, adult and neoplastic skin reveals roles for β-catenin and Notch signalling Developmental biology · 2008 · 84 citations
    8. Role of the Notch Ligand Delta1 in Embryonic and Adult Mouse Epidermis Journal of Investigative Dermatology · 2007 · 78 citations
    9. Genetic interplays between Msx2 and Foxn1 are required for Notch1 expression and hair shaft differentiation Developmental Biology · 2008 · 67 citations
    10. Localisation of members of the notch system and the differentiation of vibrissa hair follicles: Receptors, ligands, and fringe modulators Developmental dynamics · 2000 · 62 citations
    11. Notch Signaling Regulates Late-Stage Epidermal Differentiation and Maintains Postnatal Hair Cycle Homeostasis PloS one · 2011 · 61 citations
    12. Lef1 Contributes to the Differentiation of Bulge Stem Cells by Nuclear Translocation and Cross-Talk with the Notch Signaling Pathway International Journal of Medical Sciences · 2013 · 57 citations
    13. JMJD3 and NF-κB-dependent activation of Notch1 gene is required for keratinocyte migration during skin wound healing Scientific Reports · 2017 · 54 citations
    14. Adipose mesenchymal stem cells combined with platelet-rich plasma accelerate diabetic wound healing by modulating the Notch pathway Stem Cell Research & Therapy · 2021 · 39 citations
    15. Epidermal growth factor promotes proliferation of dermal papilla cells via Notch signaling pathway Biochimie · 2016 · 36 citations
    16. Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1 Development · 2010 · 34 citations
    17. Pleiotropic Role of Notch Signaling in Human Skin Diseases International Journal of Molecular Sciences · 2020 · 29 citations
    18. Notch signaling is significantly suppressed in basal cell carcinomas and activation induces basal cell carcinoma cell apoptosis Molecular Medicine Reports · 2017 · 18 citations
    19. The Notch Intracellular Domain Has an RBPj-Independent Role during Mouse Hair Follicular Development 2016 · 16 citations
    20. Pantothenic acid promotes dermal papilla cell proliferation in hair follicles of American minks via inhibitor of DNA Binding 3/Notch signaling pathway Life sciences · 2020 · 11 citations
    21. Pyridoxine regulates hair follicle development via the PI3K/Akt, Wnt and Notch signalling pathways in rex rabbits Animal nutrition · 2021 · 10 citations
    22. Keratin-6 driven ODC expression to hair follicle keratinocytes enhances stemness and tumorigenesis by negatively regulating Notch Biochemical and Biophysical Research Communications · 2014 · 8 citations
    23. Notch1 Signaling Regulates Wound Healing via Changing the Characteristics of Epidermal Stem Cells Journal of Stem Cell Research & Therapy · 2016 · 6 citations
    24. MiR-23b and miR-133 Cotarget TGFβ2/NOTCH1 in Sheep Dermal Fibroblasts, Affecting Hair Follicle Development Cells · 2024 · 4 citations
    25. Cutaneous Lymphadenoma Is a Distinct Trichoblastoma-like Lymphoepithelial Tumor With Diffuse Androgen Receptor Immunoreactivity, Notch1 Ligand in Reed-Sternberg–like Cells, and Common EGFR Somatic Mutations The American Journal of Surgical Pathology · 2021 · 4 citations
    26. An accessible pharmacodynamic transcriptional biomarker for notch target engagement Clinical Pharmacology & Therapeutics · 2016 · 4 citations
    27. 199 Impairment of notch 1 signaling is a common defect in lesions from patients with hidradenitis suppurativa Journal of Investigative Dermatology · 2017 · 2 citations
    28. MiR-23b and miR-133 cotarget TGFβ2/NOTCH1 in dermal fibroblasts and affect hair follicle development in sheep Research Square (Research Square) · 2023
    29. Epidermal Notch1 recruits innate lymphoid cells to orchestrate normal skin repair Durham e-Theses (Durham University) · 2014
    30. Cutaneous gain-of-function mutation of LRIG3 leads to alopecia by upregulation of ERBB, PI3K/AKT, NOTCH1 signaling pathways Scientific Reports · 2026