Notch1 Signaling Regulates Wound Healing by Changing the Characteristics of Epidermal Stem Cells

January 2016 in “ Journal of Stem Cell Research & Therapy ”

Bin Shu, Rui Yang

Notch1 signaling epidermal stem cells ESCs wound healing Jagged 1 siRNA knockdown re-epithelialization matrix formation skin regeneration

TLDR Notch1 signaling is crucial for improving wound healing and skin regeneration by affecting stem cell behavior.

The study from 2016 explored the impact of Notch1 signaling on wound healing and epidermal stem cells (ESCs). It was found that Notch1 signaling is upregulated during wound healing, influencing ESC characteristics. Suppression of Notch1 signaling through siRNA knockdown of its ligand Jagged 1 resulted in poor wound healing, while activation of Notch1 improved healing and affected ESC expression. In vivo experiments with 25 mice showed that those treated with JAG1 siRNA-transfected ESCs experienced delayed healing and less organized tissue compared to controls. The study concluded that Notch1 signaling is essential for ESCs' role in re-epithelialization, matrix formation, and skin regeneration, indicating its potential as a therapeutic target for enhancing wound healing and treating scarring. The number of rats used was not specified, but the mice were divided into three groups for the experiments.

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222 citations, August 2009 in “Experimental Dermatology”

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