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    Glossary Notch signaling

    cell communication system regulating development and tissue maintenance

    Notch signaling is a fundamental communication system used by cells to control various developmental processes and maintain tissue homeostasis. It involves interactions between neighboring cells through the Notch receptor and its ligands, leading to changes in gene expression that influence cell fate decisions, such as differentiation, proliferation, and apoptosis. This pathway is crucial in many biological contexts, including the development of hair follicles and the regulation of stem cells.

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    1. Epidermal Notch signalling: differentiation, cancer and adhesion Current opinion in cell biology · 2008 · 253 citations
    2. The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling Development · 2011 · 134 citations
    3. Dynamic regulation of retinoic acid-binding proteins in developing, adult and neoplastic skin reveals roles for β-catenin and Notch signalling Developmental biology · 2008 · 84 citations
    4. Pleiotropic Role of Notch Signaling in Human Skin Diseases International Journal of Molecular Sciences · 2020 · 29 citations
    5. Notch1 Signaling Regulates Wound Healing via Changing the Characteristics of Epidermal Stem Cells Journal of Stem Cell Research & Therapy · 2016 · 6 citations
    6. 199 Impairment of notch 1 signaling is a common defect in lesions from patients with hidradenitis suppurativa Journal of Investigative Dermatology · 2017 · 2 citations
    7. Cutaneous gain-of-function mutation of LRIG3 leads to alopecia by upregulation of ERBB, PI3K/AKT, NOTCH1 signaling pathways Scientific Reports · 2026
    8. Peimine Promotes Skin Wound Repair in Mice by Activating the Notch1 Signaling Pathway in Fibroblasts Food Science & Nutrition · 2025
    9. Notch Signaling in Hair Follicle Development Asian Journal of Beauty and Cosmetology · 2017
    10. Notch signaling is significantly suppressed in basal cell carcinomas and activation induces basal cell carcinoma cell apoptosis Molecular Medicine Reports · 2017 · 18 citations
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