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    Glossary Notch signaling

    cell communication system regulating development and tissue maintenance

    Notch signaling is a fundamental communication system used by cells to control various developmental processes and maintain tissue homeostasis. It involves interactions between neighboring cells through the Notch receptor and its ligands, leading to changes in gene expression that influence cell fate decisions, such as differentiation, proliferation, and apoptosis. This pathway is crucial in many biological contexts, including the development of hair follicles and the regulation of stem cells.

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    1. Epidermal Notch signalling: differentiation, cancer and adhesion Current opinion in cell biology · 2008 · 253 citations
    2. The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling Development · 2011 · 134 citations
    3. Dynamic regulation of retinoic acid-binding proteins in developing, adult and neoplastic skin reveals roles for β-catenin and Notch signalling Developmental biology · 2008 · 84 citations
    4. Pleiotropic Role of Notch Signaling in Human Skin Diseases International Journal of Molecular Sciences · 2020 · 29 citations
    5. Notch1 Signaling Regulates Wound Healing via Changing the Characteristics of Epidermal Stem Cells Journal of Stem Cell Research & Therapy · 2016 · 6 citations
    6. 199 Impairment of notch 1 signaling is a common defect in lesions from patients with hidradenitis suppurativa Journal of Investigative Dermatology · 2017 · 2 citations
    7. Cutaneous gain-of-function mutation of LRIG3 leads to alopecia by upregulation of ERBB, PI3K/AKT, NOTCH1 signaling pathways Scientific Reports · 2026
    8. Peimine Promotes Skin Wound Repair in Mice by Activating the Notch1 Signaling Pathway in Fibroblasts Food Science & Nutrition · 2025
    9. Notch Signaling in Hair Follicle Development Asian Journal of Beauty and Cosmetology · 2017
    10. Notch signaling is significantly suppressed in basal cell carcinomas and activation induces basal cell carcinoma cell apoptosis Molecular Medicine Reports · 2017 · 18 citations
    11. Pantothenic acid promotes dermal papilla cell proliferation in hair follicles of American minks via inhibitor of DNA Binding 3/Notch signaling pathway Life sciences · 2020 · 11 citations
    12. Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately Stem Cell Research & Therapy · 2015 · 113 citations
    13. Impaired Notch‐MKP‐1 signalling in hidradenitis suppurativa: an approach to pathogenesis by evidence from translational biology Experimental dermatology · 2013 · 112 citations
    14. Notch Signaling Regulates Late-Stage Epidermal Differentiation and Maintains Postnatal Hair Cycle Homeostasis PloS one · 2011 · 61 citations
    15. Lef1 Contributes to the Differentiation of Bulge Stem Cells by Nuclear Translocation and Cross-Talk with the Notch Signaling Pathway International Journal of Medical Sciences · 2013 · 57 citations
    16. Epidermal growth factor promotes proliferation of dermal papilla cells via Notch signaling pathway Biochimie · 2016 · 36 citations
    17. Pyridoxine regulates hair follicle development via the PI3K/Akt, Wnt and Notch signalling pathways in rex rabbits Animal nutrition · 2021 · 10 citations
    18. Melanoblasts' Proper Location and Timed Differentiation Depend on Notch/RBP-J Signaling in Postnatal Hair Follicles 2008 · 70 citations
    19. Accelerated Endothelial to Mesenchymal Transition Increased Fibrosis via Deleting Notch Signaling in Wound Vasculature Journal of Investigative Dermatology · 2017 · 26 citations
    20. Hemidesmosomes and Notch signaling regulate epidermal differentiation via delamination Development · 2026
    21. Role of Notch signaling in cell fate determination of dental epithelial stem/progenitor cells Zurich Open Repository and Archive (University of Zurich) · 2017
    22. Targeting Wnt/β-catenin signaling and its interplay with TGF-β and Notch signaling pathways for the treatment of chronic wounds Cell Communication and Signaling · 2024 · 74 citations
    23. Rab5c-mediated endocytic trafficking regulates hematopoietic stem and progenitor cell development via Notch and AKT signaling PLoS Biology · 2020 · 32 citations
    24. Genetic interplays between Msx2 and Foxn1 are required for Notch1 expression and hair shaft differentiation Developmental Biology · 2008 · 67 citations
    25. Adipose mesenchymal stem cells combined with platelet-rich plasma accelerate diabetic wound healing by modulating the Notch pathway Stem Cell Research & Therapy · 2021 · 39 citations
    26. Signaling Involved in Hair Follicle Morphogenesis and Development International Journal of Molecular Sciences · 2014 · 223 citations
    27. Roles of the Hedgehog Signaling Pathway in Epidermal and Hair Follicle Development, Homeostasis, and Cancer Journal of developmental biology · 2017 · 72 citations
    28. Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1 Development · 2010 · 34 citations
    29. The Notch Intracellular Domain Has an RBPj-Independent Role during Mouse Hair Follicular Development 2016 · 16 citations
    30. Keratin-6 driven ODC expression to hair follicle keratinocytes enhances stemness and tumorigenesis by negatively regulating Notch Biochemical and Biophysical Research Communications · 2014 · 8 citations