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    Did you mean Notch signaling?
    Glossary Notch signaling

    cell communication system regulating development and tissue maintenance

    Notch signaling is a fundamental communication system used by cells to control various developmental processes and maintain tissue homeostasis. It involves interactions between neighboring cells through the Notch receptor and its ligands, leading to changes in gene expression that influence cell fate decisions, such as differentiation, proliferation, and apoptosis. This pathway is crucial in many biological contexts, including the development of hair follicles and the regulation of stem cells.

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      community Reducing Fibrosis in Hair Loss: Topical Pirfenidone

       59 upvotes 5 months ago
      Topical pirfenidone is highlighted as an effective anti-inflammatory and anti-fibrotic treatment for hair loss, particularly in addressing perifollicular fibrosis, which may enhance the effectiveness of standard treatments like finasteride and minoxidil. The user also uses calcipotriol, MCT oil, ciclopirox shampoo, and benzoyl peroxide shampoo as part of their regimen.

      community Yes your lifestyle and diet has its role in hair loss.

      in Chat  296 upvotes 1 year ago
      Diet and lifestyle changes can reduce hair shedding but won't regrow hair lost to genetic male pattern baldness. Treatments like finasteride and dutasteride are necessary for significant hair regrowth.

      community What if DHT is not the vilan.

       13 upvotes 5 years ago
      Hair loss may be influenced more by inflammation, microbiome imbalances, and gut health than DHT. Treatments discussed include minoxidil, finasteride, RU58841, fecal microbiota transplants, and JAK inhibitors.

      community Shoutout to Zinc pyrithione and Piroctone olamine

       3 upvotes 1 year ago
      Zinc pyrithione and piroctone olamine are effective for reducing hair shedding, possibly more so than ketoconazole. There is a concern about zinc pyrithione shampoo interfering with minoxidil, but it's unclear if this is proven.

      community Joined the Dutasteride Master Race

       586 upvotes 1 year ago
      Dutasteride and finasteride are discussed for hair loss treatment, with users sharing experiences and debating their effectiveness and side effects. Celebrities are noted as common users, and there is debate over which treatment is superior.

      community Thomas Sowell's hair at age 95

       347 upvotes 5 months ago
      Thomas Sowell's youthful appearance at age 95, with comments on his hair and overall looks. Some suggest using treatments like minoxidil and finasteride to maintain hair.

      community Massive shedding not stoping for more than 2 months

      in Treatment  8 upvotes 1 month ago
      A 21-year-old with AGA and seborrheic dermatitis experienced significant hair improvement using 1 mg finasteride and 2 mg oral minoxidil but began shedding heavily after a few months. Despite not missing any doses, the shedding persisted for over two months, causing concern about the effectiveness of the treatment.

      community Almost 4 months on fin/dut, 2.5 months on min

       126 upvotes 3 months ago
      The user has been using finasteride and dutasteride for hair loss, along with minoxidil and ketoconazole shampoo, due to early onset male pattern baldness and family history. They switched from finasteride to dutasteride after two months and have been using a dermaroller weekly.

      community 7 months on dutasteride + oral minoxidil + nizoral - progress pics

       54 upvotes 5 months ago
      The user reported progress in hair growth after 7 months using dutasteride, oral minoxidil (2.5 mg once daily), and Nizoral, noting improvements in hair thickness and density. The user experienced no side effects and plans to continue the treatment.

      community 3 week hair transplant update - HLC Ankara - How's it looking?

       69 upvotes 6 months ago
      A 35-year-old shared a 3-week update on their hair transplant of 3153 grafts at HLC Ankara, noting no shedding yet and using finasteride for over 13 years. They praised the clinic's professionalism and manual extraction method, spending over $10,000 for the procedure and accommodations.

      community Around 5 month update (24m) (min + fin)

      in Progress Pictures  279 upvotes 9 months ago
      A 24-year-old shared impressive hair regrowth results after 5 months using oral minoxidil (3mg) and finasteride (1mg) daily, along with weekly microneedling, without side effects. The user self-medicated through the Hims website and noticed significant changes by the third month.

      community Took the plunge, bros. 3500 grafts later..

      in Transplants  167 upvotes 1 year ago
      A user underwent a hair transplant with 3500 grafts after trying treatments like finasteride and minoxidil, preferring a local clinic in Toronto over traveling to Turkey. The user plans to continue using finasteride to maintain existing hair, as the transplanted hair is DHT resistant.

      community HT Update – 36 Days Post-Op (5500 Grafts, Delhi)

       22 upvotes 1 year ago
      A user shared their experience 36 days after a hair transplant of 5500 grafts in Delhi, using topical minoxidil and finasteride, and plans to start oral finasteride. They reported less shedding than expected and strong early growth, while also maintaining a healthy lifestyle.

      community 4600 FUT Hair Transplant 16 month post second surgery progress

      in Transplants  3725 upvotes 1 year ago
      The user had two FUT hair transplants with 4,600 grafts for increased density, costing about $11,000 each, and has been using oral minoxidil and finasteride for over five years without side effects. The results are natural-looking with no visible scarring, and the user finds the procedure valuable despite the cost.

      community (37M) Major progress! One side significantly better than the other, but I have a theory.

       25 upvotes 3 years ago
      A 37-year-old man reports significant hair regrowth using a regimen of topical minoxidil, oral finasteride, derma rolling, and saw palmetto shampoo, but notices uneven progress between the sides of his head. He theorizes that sleeping on one side might affect hair growth, but others suggest it could be unrelated to sleeping habits.

      community This is Brad Pitt @ 59 years old

       2651 upvotes 3 years ago
      The conversation is about Brad Pitt's hair and whether he has had a hair transplant or used finasteride. Some users believe that his good genetics and lifestyle choices are responsible for his hair, while others think he may have had cosmetic procedures or used hair loss treatments.

      community Finasteride ruined my hair, and my life (so far)

       9 upvotes 4 years ago
      The user suspects finasteride worsened their hair loss despite no abnormal shedding and reduced hair fall initially. They are considering various options, including switching brands, trying topical finasteride, oral minoxidil, or waiting for new treatments.

      community Do you think most celebrities use Dutasteride instead of Finasteride?

       62 upvotes 2 months ago
      Celebrities may use Dutasteride for hair loss, but opinions vary on whether it's more common than Finasteride. Some believe Dutasteride is preferred due to its effectiveness, while others think Finasteride is more widely used, especially among athletes.

      community Crown Christmas Miracle: Back From the Dead 💀

       2107 upvotes 8 months ago
      A 42-year-old man achieved significant hair regrowth in seven months using oral minoxidil, oral dutasteride, topical minoxidil, microneedling, and supplements. He experienced minimal side effects and noted dramatic improvements in hair thickness and health.

      community Did George Clooney did a hair transplant?

       2609 upvotes 10 months ago
      George Clooney likely had a hair transplant, as many Hollywood actors do to maintain their appearance. Treatments like finasteride and hair transplants are common among celebrities to combat hair loss.

      community No longer seeing any progress, really worried and panicking.

       114 upvotes 11 months ago
      The user is experiencing increased hair thinning and shedding despite using oral dutasteride, oral minoxidil, topical dutasteride, and ketoconazole shampoo. Many recommend considering a hair transplant or embracing baldness, as current treatments seem ineffective.

      community Is this real chat? Finasteride -> fountain of youth and longevity drug?

       559 upvotes 1 year ago
      Finasteride is discussed as a hair loss treatment with benefits like reduced prostate enlargement and skin aging, but it is not seen as a "fountain of youth." Users report mixed experiences, including side effects like decreased libido and dry eyes.

      community Taking Finasteride and Creatine.

       11 upvotes 1 year ago
      Finasteride may help prevent hair loss for those concerned about creatine, despite no proven link between creatine and hair loss. Personal experiences with creatine and hair shedding vary.

      community Please do not get a Hair Transplant in Turkey

      in Transplants  859 upvotes 1 year ago
      Hair transplants in Turkey can be risky due to unqualified practitioners and high patient volumes, but some clinics offer good results if researched properly. It's crucial to choose a reputable clinic and doctor, as experiences vary widely.
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