An Accessible Pharmacodynamic Transcriptional Biomarker for Notch Target Engagement

    February 2016 in “ Clinical Pharmacology & Therapeutics ”
    Keith Q. Tanis, Alexei A. Podtelezhnikov, Samuel C. Blackman, Jeremy Hing, Radha Railkar, Jared Lunceford, Joel A. Klappenbach, Bo Wei, Amy Harman, Luiz Miguel Camargo, Sanjiv Shah, Eva M. Finney, James S. Hardwick, Andrey Loboda, James Watters, Donald A. Bergstrom, Tim Demuth, Gary Herman, Peter R. Strack, Robert Iannone
    Image of study
    TLDR Hair follicle samples effectively show how well the drug MK-0752 targets and engages with the Notch pathway.
    The document reports on a clinical trial that investigated the effects of the gamma-secretase inhibitor MK-0752 on gene expression related to the Notch signaling pathway. The trial included 24 subjects who were given MK-0752 or a placebo, and their blood and hair follicle samples were analyzed for changes in a predefined 11-gene Notch signature. The study found that hair follicle samples were more reliable than blood samples for analysis, with 430 hair follicle samples passing quality control compared to 119 blood samples. The Notch signature score in hair follicles was identified as a reliable biomarker for MK-0752 target engagement, and the drug was found to be well-tolerated. The study was funded by Merck & Co., Inc., and the authors disclosed their employment and stock ownership in the company.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 12 results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community The Worst Hair Loss Condition You (MAY) have: LPP

      in Research/Science  43 upvotes 3 months ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

      community Vitamin E

       20 upvotes 6 years ago
      Vitamin E was discussed as a treatment for hair shedding, with a specific form mentioned. A user shared a link to a study and started taking the Vitamin E variants used.

      community What happened to that guy who’s been drinking topical minoxidil?!

      in Chat  217 upvotes 1 month ago
      A user tried various hair growth treatments, including drinking topical minoxidil, using oral minoxidil and finasteride, and applying GHK-Cu, growth hormone peptides, and liposomal sulforaphane. They experienced thicker hair, while others discussed the risks and benefits of these methods.

    Similar Research

    5 / 1000+ results