May 2026 in “Advanced Pharmaceutical Bulletin” In this study, black cumin oil-based nanostructured lipid carriers enhanced the delivery and effectiveness of fluticasone for psoriasis in a mouse model, improving skin targeting, inflammation reduction, and permeability compared to standard cream.
January 2022 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study found that the optimized nanostructured lipid carrier formulation effectively enabled caffeine to penetrate and accumulate in hair follicles, suggesting potential for intrafollicular delivery in treatments for hair loss.
89 citations
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November 2014 in “International Journal of Nanomedicine” This study suggests that spironolactone-loaded nanostructured lipid carriers could enhance follicular delivery and offer a more localized treatment for androgenic alopecia, potentially reducing systemic side effects.
59 citations
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October 2012 in “Pharmaceutical Research” This study found that nanostructured lipid carriers with more soybean phosphatidylcholine provided better skin retention and follicular targeting for diphencyprone compared to other formulations and controls.
59 citations
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September 2021 in “Cosmetics” This review discusses lipid nanoparticle-based cosmetics, emphasizing their potential in protecting skin from radiation and treating conditions like atopic dermatitis and psoriasis with synthetic and natural antioxidants. It highlights recent research on these formulations' effectiveness in alleviating skin disorders and enhancing skin health.
47 citations
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April 2017 in “European Journal of Pharmaceutics and Biopharmaceutics” This study found that dutasteride-loaded nanostructured lipid carriers coated with a stearic acid-chitosan oligomer are stable, less cytotoxic, and suitable for topical delivery to promote hair growth.
46 citations
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September 2018 in “Expert Opinion on Drug Delivery” This study reported that nanostructured lipid carriers with melatonin improved hair density and decreased hair loss in patients with androgenic alopecia, suggesting a promising direction for future treatments.
44 citations
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August 2017 in “Food Bioscience” This study found that betasitosterol-loaded nanostructured lipid carriers, when added to butter, improved its nutritional profile and antioxidant properties, maintaining stability over a three-month storage period.
40 citations
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March 2019 in “Pharmaceutical development and technology” The study found that cyproterone acetate-loaded nanostructured lipid carriers, particularly those with a 300 nm diameter, improved skin penetration and targeted hair follicles more effectively than free cyproterone acetate.
38 citations
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November 2016 in “Aaps Pharmscitech” This study found that the nanostructured lipid carrier formulation with a 70:30 solid to liquid lipid ratio significantly increased the dissolution rate, entrapment efficiency, and stability of spironolactone compared to its raw form.
28 citations
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March 2014 in “International Journal of Nanomedicine” This study developed lipid nanoparticles for delivering minoxidil and finasteride to the dermis and hair follicles, showing stability and a desired prolonged release, though with low skin penetration levels.
17 citations
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April 2021 in “Biointerface Research in Applied Chemistry” This review discusses nanostructured lipid carriers and their potential applications in pharmaceuticals and food, offering no new clinical findings but highlighting recent advancements and patents.
17 citations
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October 2016 in “Artificial Cells Nanomedicine and Biotechnology” This study found that arginine-loaded lipidic nanoparticles improved hair follicle growth in male hamsters more effectively than an aqueous arginine solution.
15 citations
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May 2016 in “Die Pharmazie” This study found that nanostructured lipid carriers provided better skin-targeted delivery and drug loading for lidocaine than nanoethosomes, indicating improved local anesthetic efficacy in vitro.
8 citations
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October 2020 in “Pharmaceutics” This study explored using a chitosan oligomer coating for topical delivery of dutasteride-loaded nanostructured lipid carriers, aiming to reduce systemic exposure and cytotoxicity.
8 citations
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September 2023 in “Advanced Pharmaceutical Bulletin” In a double-blind clinical trial, this study found that a gel containing chitosan-coated spironolactone nanoparticles effectively reduced acne lesions over 8 weeks without adverse skin effects, suggesting potential for enhanced acne treatment through targeted skin delivery.
5 citations
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March 2016 in “Drug Development and Industrial Pharmacy” This article reviews the promising ease of drug administration via transdermal and other topical routes, highlighting their potential for high patient compliance and reduced side effects but provides no new clinical results.
2 citations
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January 2025 in “Naunyn-Schmiedeberg s Archives of Pharmacology” Nanostructured lipid carriers can improve alopecia treatment by enhancing drug delivery and promoting hair growth.
2 citations
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January 2018 in “Elsevier eBooks” This review discusses the use of lipid nanoparticles for topical and transdermal delivery of pharmaceuticals and cosmeceuticals and reports no new clinical results.
1 citations
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July 2021 in “Current nanomedicine” This study found that nanostructured lipid carriers could serve as a promising vehicle for topical Acitretin delivery in psoriasis treatment, potentially reducing oral side effects and enhancing patient compliance.
1 citations
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June 2019 in “International Journal of Applied Pharmaceutics” In this study, nanostructured lipid carriers for hair split-end repair showed similar efficacy regardless of charge, with negatively charged carriers exhibiting better stability over six months compared to positively charged ones.
July 2026 in “Journal of Drug Delivery and Therapeutics” This study evaluated Finasteride-loaded nanostructured lipid carriers for topical use in treating androgenetic alopecia and found that these carriers offer sustained drug release and may reduce systemic side effects compared to oral administration.
July 2026 in “Drug Delivery Letters” This review discusses the potential of nanostructured lipid carriers to improve herbal treatments for alopecia and reports no new clinical results, highlighting the need for further clinical trials and safety data.
This study found that nanostructured lipid carriers enabled effective follicular delivery and accumulation of anti-hair loss drugs like dutasteride in mice, suggesting potential for reduced dosage frequency.
This study found that nanostructured lipid carriers significantly improved the targeted delivery of latanoprost and minoxidil to pilosebaceous units in porcine skin, with latanoprost showing notably higher accumulation.
January 2026 in “Pharmaceutical Development and Technology” This study found that nanostructured lipid carriers containing tea seed or lavender oil improved hair regrowth in female Wistar rats over 30 days, showing greater effectiveness compared to a commercial product and placebo, attributed to enhanced follicular penetration and stability.
January 2026 in “Advances in health and disease” This collection of research papers details a range of health topics, including iodine's essential role across biological kingdoms, holistic health factors, advances in pediatric practice, the complexity of sinus septa in medical procedures, and innovative delivery methods for treating hair loss with nanostructured lipid carriers.
October 2025 in “Journal of Drug Delivery Science and Technology” This study suggests that combining scalp cooling with resveratrol-loaded nanoparticles effectively protects hair follicles from chemotherapy-induced damage, highlighting a potential method to prevent hair loss during cancer treatment.
December 2024 in “Pharmaceutics” This review systematically examined recent advancements in spironolactone-loaded nanocarriers, revealing that lipid and vesicular nanoparticles enhance bioavailability and skin penetration for treating androgen-dependent disorders, but highlighted the need for further clinical studies to optimize their use.
December 2024 in “International Journal of Drug Delivery Technology” This study reports that a novel Nano-Structured Lipid Carrier system for delivering dutasteride may enhance its anticancer effects while reducing systemic side effects in clinical settings.