Fabrication and In Vitro Evaluation of Silk Fibroin-Folic Acid Decorated Paclitaxel and Hydroxyurea Nanostructured Lipid Carriers for Targeting Ovarian Cancer Cells: A Double Sword Approach

    February 2023 in “ Journal of drug delivery science and technology ”
    Praharsh Kumar Mandadhi Rajendra, Bala Sai Soujith Nidamanuri, Akey Krishna Swaroop, Janani Selvam Krishnamurali, Anjali Puthusserikkunnu Balan, Jubie Selvaraj, R. Raman, H.N. Shivakumar, Murthannagari Vivek Reddy, N Jawahar
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    TLDR The new drug carriers show promise for better targeting and treating ovarian cancer.
    In this study, silk fibroin-folic acid (SF-FA) conjugate was used to decorate paclitaxel-loaded and hydroxyurea-loaded nanostructured lipid carriers (NLCs) for targeted ovarian cancer treatment. These NLCs showed small particle size, high entrapment efficiency, and spherical shape, with sustained drug release following first-order kinetics and fickian diffusion. In vitro tests on human ovarian cancer SKOV-3 cells demonstrated enhanced cytotoxicity, indicating that SF-FA NLCs could be an effective targeted drug delivery system for ovarian cancer therapy.
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