Targeting Potential of Zinc Oxide Nanoparticles and Finasteride-Loaded Nano Lipidic Carriers-Infused Topical Gel: In Vitro and In Vivo Skin Permeation Studies

    November 2023
    Shweta Ramkar, Preeti K. Suresh
    Studysummary In this study, researchers developed a novel gel formulation combining zinc oxide nanoparticles and finasteride-loaded nanostructured lipid carriers, which showed promising results for topical delivery and effective skin penetration, potentially offering a new treatment approach for androgenic alopecia.
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    Research cited in this study 13

    1. Novel Iron Oxide Nanocarriers Loading Finasteride or Dutasteride: Enhanced Skin Penetration for Topical Treatment of Alopecia International Journal of Pharmaceutics · 2020
    2. Serum Biotin and Zinc in Male Androgenetic Alopecia Journal of Cosmetic Dermatology · 2019
    3. Histological Evaluation of Follicular Delivery of Arginine via Nanostructured Lipid Carriers: A Novel Potential Approach for the Treatment of Alopecia Artificial Cells Nanomedicine and Biotechnology · 2016
    4. Preparation and Characterization of Minoxidil Loaded Nanostructured Lipid Carriers Aaps Pharmscitech · 2016
    5. A Guide to Studying Human Hair Follicle Cycling In Vivo Journal of Investigative Dermatology · 2015
    6. Evaluation of Serum Zinc Level in Patients With Newly Diagnosed and Resistant Alopecia Areata International Journal of Dermatology · 2015
    7. Follicular Delivery of Spironolactone via Nanostructured Lipid Carriers for Management of Alopecia International Journal of Nanomedicine · 2014
    8. Design and In Vitro Evaluation of Finasteride-Loaded Liquid Crystalline Nanoparticles for Topical Delivery Aaps Pharmscitech · 2012
    9. Formulation and In Vitro Assessment of Minoxidil Niosomes for Enhanced Skin Delivery International Journal of Pharmaceutics · 2009
    10. Dermal Delivery of Topically Applied Oligonucleotides via Follicular Transport in Mouse Skin Journal of Investigative Dermatology · 2005
    11. Hair Follicle Pigmentation: Mechanisms and Factors Influencing Melanin Production ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2005
    12. Nutritional Factors and Hair Loss Clinical and Experimental Dermatology · 2002
    13. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998

    Related research 4

    1. Similar Efficacy of Maintenance Treatment of Finasteride 1 mg Every Other Month Compared with Finasteride 1 mg Daily in Korean Men with Androgenetic Alopecia After Taking Finasteride 1 mg Daily for 1 Year Journal of The American Academy of Dermatology · 2020
    2. Finasteride in the Treatment of Japanese Men with Male Pattern Hair Loss PubMed · 2004
    3. Advances in the Treatment of Male Androgenetic Alopecia: A Brief Review of Finasteride Studies PubMed · 2001
    4. Finasteride Inhibits 5α-Reductase Activity in Human Dermal Fibroblasts: Prediction of Its Therapeutic Application in Androgen-Related Skin Diseases International Journal of Dermatology · 1995