Targeting Potential of Zinc Oxide Nanoparticles and Finasteride-Loaded Nano Lipidic Carriers-Infused Topical Gel: In Vitro and In Vivo Skin Permeation Studies

November 2023

Shweta Ramkar, Preeti K. Suresh

zinc oxide nanoparticles finasteride nano lipidic carriers topical gel androgenic alopecia Carbopol gel skin permeation drug delivery ZnO nanoparticles NLCs hair loss skin absorption

TLDR The new gel with Zinc Oxide nanoparticles and finasteride shows promise for treating hair loss when applied to the skin.

The study aimed to develop a novel formulation combining Zinc Oxide (ZnO) nanoparticles and finasteride-loaded Nano Lipidic Carriers (NLCs) for topical delivery in the treatment of androgenic alopecia. The ZnO nanoparticles were synthesized and incorporated within a Carbopol gel, which was then evaluated for its physicochemical characteristics. The particle size of the nanoparticles was found to be 200 nm, and the gel had a pH of 6.13±2.11, viscosity of 35,845.3±6.97 cps at 5 rpm, and spreadability of 17.14±2.32. Ex vivo drug permeation and skin distribution studies on rat dorsal skin showed 25.763±0.2 μg/cm² and 19.375±1.2 μg/cm² of finasteride and ZnO in 12 hours respectively. The results suggest that the developed systems have potential for topical drug delivery in the treatment of androgenic alopecia.

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11 / 11 results

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research Histological Evaluation of Follicular Delivery of Arginine via Nanostructured Lipid Carriers: A Novel Potential Approach for the Treatment of Alopecia

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research Follicular Delivery of Spironolactone via Nanostructured Lipid Carriers for Management of Alopecia

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research Formulation and In Vitro Assessment of Minoxidil Niosomes for Enhanced Skin Delivery

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research Hair Follicle Pigmentation: Mechanisms and Factors Influencing Melanin Production

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research Nutritional Factors and Hair Loss

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research Finasteride in the Treatment of Men with Androgenetic Alopecia

581 citations , October 1998 in “Journal of The American Academy of Dermatology”

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research Similar Efficacy of Maintenance Treatment of Finasteride 1 mg Every Other Month Compared with Finasteride 1 mg Daily in Korean Men with Androgenetic Alopecia After Taking Finasteride 1 mg Daily for 1 Year

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research Finasteride in the Treatment of Japanese Men with Male Pattern Hair Loss

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research Advances in the Treatment of Male Androgenetic Alopecia: A Brief Review of Finasteride Studies

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research Finasteride Inhibits 5α-Reductase Activity in Human Dermal Fibroblasts: Prediction of Its Therapeutic Application in Androgen-Related Skin Diseases

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