Acitretin Loaded Nanocarrier Gel: Formulation and Exploration of In-Vitro Release Kinetics
July 2021
in “
Current nanomedicine
”
New to oleic acid? There is a guide in the encyclopedia. Read the guide → Studysummary This study found that nanostructured lipid carriers could serve as a promising vehicle for topical Acitretin delivery in psoriasis treatment, potentially reducing oral side effects and enhancing patient compliance. Our plain-language summary of this paper — not a Tressless recommendation.
The study aimed to develop a topical formulation of Acitretin (ACT), a vitamin A analog used for managing psoriasis, to enhance patient compliance and reduce oral toxicity. ACT loaded Nanostructured Lipid Carriers (NLCs) were prepared using a hot homogenization method with oleic acid and stearic acid in a 7:3 ratio, along with a combination of non-ionic and anionic surfactants. The optimized formulation had a mean diameter of 363 nm and exhibited an amorphous nature. It was incorporated into a gel using Carbopol 940P as a gelling agent. In vitro release studies showed a 96.85 ± 2% release in 8 hours with Korsmeyer-Peppas model release kinetics. The study concluded that NLCs can serve as a potential carrier for topical delivery of ACT, reducing oral toxicity associated with the drug.
