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GlossaryNF-κB pathway

regulates genes involved in immune and inflammatory responses

The NF-κB pathway, short for Nuclear Factor kappa-light-chain-enhancer of activated B cells pathway, is a critical signaling mechanism in cells that regulates the expression of genes involved in immune and inflammatory responses. When activated, it can lead to the production of proteins that help fight infections and repair tissue damage, but its chronic activation is also linked to various diseases, including cancer and autoimmune disorders.

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Melatonin Promotes the Development of Secondary Hair Follicles in Adult Cashmere Goats by Activating the Keap1-Nrf2 Signaling Pathway and Inhibiting the Inflammatory Transcription Factors NFkB and AP-1

research Melatonin Promotes the Development of Secondary Hair Follicles in Adult Cashmere Goats by Activating the Keap1-Nrf2 Signaling Pathway and Inhibiting the Inflammatory Transcription Factors NFkB and AP-1

1 citations, February 2023 in “International Journal of Molecular Sciences”

Melatonin improves cashmere goat hair quality by increasing follicles and reducing skin aging.

research Transcriptional Activation of a Subset of Hair Keratin Genes by the NF-κB Effector p65/RelA

7 citations, November 2007 in “Differentiation”

The NF-κB effector p65/RelA activates hair keratin genes, aiding hair formation.

Transcriptome Dynamics Reveal Stage-Specific and Melatonin-Triggered Gene Expression Patterns During the Cashmere Growth Cycle in Capra Hircus

research Transcriptome Dynamics Reveal Stage-Specific and Melatonin-Triggered Gene Expression Patterns During the Cashmere Growth Cycle in Capra Hircus

October 2021 in “Research Square (Research Square)”

Melatonin affects certain genes and pathways involved in cashmere goat hair growth.

Construction and Functional Analysis of CeRNA Regulatory Network Related to the Development of Secondary Hair Follicles in Inner Mongolia Cashmere Goats

research Construction and Functional Analysis of CeRNA Regulatory Network Related to the Development of Secondary Hair Follicles in Inner Mongolia Cashmere Goats

2 citations, August 2022 in “Frontiers in Veterinary Science”

The research found key RNA networks that may control hair growth in cashmere goats.

research XEDAR Activates the Non-Canonical NF-κB Pathway

18 citations, August 2015 in “Biochemical and Biophysical Research Communications”

XEDAR triggers a specific signaling pathway in cells.

research Forsythiasides: A Review of the Pharmacological Effects

2 citations, July 2022 in “Frontiers in Cardiovascular Medicine”

Forsythiasides have multiple health benefits but may cause pseudoallergic reactions, and more research is needed.

research Modeling of Solar UV-Induced Photodamage on the Hair Follicles in Human Skin Organoids

January 2024 in “Journal of tissue engineering”

Sunlight exposure damages hair follicles, but certain stem cell-derived particles can reduce this damage and help with hair regeneration.

research RANKL Induces Organized Lymph Node Growth by Stromal Cell Proliferation

42 citations, December 2011 in “The journal of immunology/The Journal of immunology”

RANKL causes lymph nodes to grow by making certain cells multiply.

Peripheral Blood Gene Expression in Alopecia Areata Reveals Molecular Pathways Distinguishing Heritability, Disease, and Severity

research Peripheral Blood Gene Expression in Alopecia Areata Reveals Molecular Pathways Distinguishing Heritability, Disease, and Severity

20 citations, June 2010 in “Genes and Immunity”

Blood tests can help understand the genetic differences in people with alopecia areata, including how severe it is and if it's inherited.

research Transcriptome Dynamics Reveal Stage-Specific and Melatonin-Triggered Gene Expression Patterns During the Cashmere Growth Cycle in Capra Hircus

June 2021 in “Research Square (Research Square)”

Melatonin can increase cashmere yield by altering gene expression and restarting the growth cycle early.

research Genetic Basis of Skin Appendage Development

111 citations, January 2007 in “Seminars in cell & developmental biology”

Hair, teeth, and mammary glands develop similarly at first but use different genes later.

Time-Course RNA-Seq Analysis Reveals Stage-Specific and Melatonin-Triggered Gene Expression Patterns During the Hair Follicle Growth Cycle in Capra Hircus

research Time-Course RNA-Seq Analysis Reveals Stage-Specific and Melatonin-Triggered Gene Expression Patterns During the Hair Follicle Growth Cycle in Capra Hircus

9 citations, February 2022 in “BMC Genomics”

Melatonin affects gene expression in goat hair follicles, potentially increasing cashmere production.

research Clinical and Immunological Phenotype of Patients With Primary Immunodeficiency Due to Damaging Mutations in NFKB2

98 citations, March 2019 in “Frontiers in immunology”

Damaging mutations in NFKB2 cause a severe and distinct form of primary immunodeficiency with early-onset and often ACTH-deficiency.

research Identification of N6-Methyladenosine-Related Factors and the Prediction of the Regulatory Mechanism of Hair Follicle Development in Rex and Hycole Rabbits

November 2023 in “Biology”

N6-methyladenosine affects hair follicle development differently in Rex and Hycole rabbits.

research Phosphodiesterase (PDE) Inhibitors for the Treatment of Inflammatory Skin Conditions

January 2018 in “Springer eBooks”

PDE inhibitors, especially PDE4 inhibitors like apremilast, are effective for certain inflammatory skin conditions but have side effects and can be costly.

research A Holistic Approach to Antiaging as an Adjunct to Antiaging Procedures: A Review of the Literature

18 citations, January 2017 in “Dermatologic Surgery”

Combining cosmetic procedures with lifestyle changes improves antiaging results.

research A Mixture of Tocopherol Acetate and L-Menthol Synergistically Promotes Hair Growth in C57BL/6 Mice

7 citations, December 2020 in “Pharmaceutics”

A mix of tocopherol acetate and L-menthol helps grow hair better than using them separately or using minoxidil.

research Botanicals With Dermatologic Properties Derived From First Nations Healing: Part 1—Trees

4 citations, February 2017 in “Journal of Cutaneous Medicine and Surgery”

Compounds from certain trees used by First Nations people show potential for treating skin conditions and promoting hair growth, but more research is needed to confirm their safety and effectiveness.

research Reversing Gray Hair: Inspiring the Development of New Therapies Through Research on Hair Pigmentation and Repigmentation Progress

2 citations, January 2023 in “International journal of biological sciences”

Gray hair can potentially be reversed, leading to new treatments.

Bioinformatics and Network Pharmacology Identify the Therapeutic Role and Potential Mechanism of Melatonin in Alzheimer's Disease and Rosacea

research Bioinformatics and Network Pharmacology Identify the Therapeutic Role and Potential Mechanism of Melatonin in Alzheimer's Disease and Rosacea

13 citations, November 2021 in “Frontiers in Immunology”

Melatonin could be an effective treatment for Alzheimer's Disease and rosacea.

research The Effects of Methylated Flavonoids on Depression-Like Activity and Pro-Inflammatory Cytokine Thresholds in Mice Induced by Repeated Finasteride Administration

1 citations, January 2021 in “European Journal of Inflammation”

Methylated flavonoids may effectively reduce depression and inflammation caused by finasteride.

research Cell Death in Skin Function, Inflammation, and Disease

12 citations, August 2022 in “Biochemical Journal”

Different types of cell death affect skin health and inflammation, and understanding them could improve treatments for skin diseases.

research Advanced Polymer Hydrogels That Promote Diabetic Ulcer Healing: Mechanisms, Classifications, and Medical Applications

6 citations, February 2023 in “Biomaterials Research”

Special gels help heal diabetic foot sores and reduce the risk of amputation or death.

research Plumbagin, A Natural Compound With Several Biological Effects And Anti-Inflammatory Properties

2 citations, May 2023 in “Life”

Plumbagin may help protect cells, reduce inflammation, and has potential for treating various diseases, but more research is needed.

research Skin Applications of Cannabidiol: Sources, Effects, Delivery Systems, Marketed Formulations and Safety

1 citations, March 2023 in “Phytochemistry Reviews”

CBD may improve skin and hair health, but its effective use and safety need more research.

research Symposium Proceedings of the 4th Intercontinental Meeting of Hair Research Societies: The World of Hair 2004

November 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

The 2004 hair research meeting presented new findings on hair cell differentiation, genetic factors in hair loss, hair pigmentation, and potential targeted therapies.

research Sebum Free Fatty Acids Enhance the Innate Immune Defense of Human Sebocytes by Upregulating Beta-Defensin-2 Expression

195 citations, December 2009 in “Journal of Investigative Dermatology”

Free fatty acids in sebum boost skin's defense against acne by increasing antimicrobial peptides.

research NF-κB in Biology and Targeted Therapy: New Insights and Translational Implications

1 citations, March 2024 in “Signal transduction and targeted therapy”

NF-κB signaling is crucial in many diseases and can be targeted for new treatments.

research Epigallocatechin-3 Gallate Inhibits STAT-1/JAK2/IRF-1/HLA-DR/HLA-B and Reduces CD8 NKG2D Lymphocytes in Alopecia Areata Patients

15 citations, December 2018 in “International journal of environmental research and public health/International journal of environmental research and public health”

EGCG may help treat alopecia areata by blocking certain immune responses and reducing specific harmful immune cells.

research The Acne-Treatment Potential of Cinnamomum Camphora Chvar. Borneol Essential Oil In Vitro and In Vivo

August 2021 in “Research Square (Research Square)”

Borneol Essential Oil could be a natural and safe acne treatment.