PKCδ/MAPKs and NF-κB Pathways Involved in Regulation of Ingenane-Type Diterpenoids from Euphorbia Neriifolia on Macrophage Function

    Mingyan Jiang, Yong Xue, Jianchun Li, Kairui Rao, Shili Yan, Hongmei Li, Xuan‐Qin Chen, Rong‐Tao Li, Dan Liu
    TLDR Euph E and Euri A from Euphorbia neriifolia help control inflammation and immune response in cells.
    The study demonstrated that Euph E and Euri A, ingenane-type diterpenoids from Euphorbia neriifolia, exhibited multidirectional regulation on cytokines and immune function of macrophages, along with notable anti-inflammatory activity. This regulation was closely associated with the PKCδ/MAPKs and NF-κB signaling pathways.
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