Premature Aging and Cancer Development in Transgenic Mice Lacking Functional CYLD

January 2019 in “ Aging ”

Josefa P. Alameda, Ángel Ramı́rez, Rosa A. García‐Fernández, Manuel Navarro, Angustias Page, José C. Segovia, Rebeca Sánchez‐Domínguez, Cristian Suárez-Cabrera, Jesús M. Paramio, Ana Bravo, María Jesús Fernández‐Aceñero, M. Casanova

CYLD alopecia epidermis hair follicles sebaceous glands NF-κB pathway Akt JNK c-Myc chronic inflammation

TLDR Lack of functional CYLD in mice leads to early aging and cancer.

The study on K5-CYLDC/S transgenic mice lacking functional CYLD demonstrated that the absence of CYLD's deubiquitinase function led to premature aging and increased cancer risk. These mice showed signs of accelerated aging, such as alopecia and kyphosis, and developed spontaneous tumors in various organs, including the skin, lung, liver, and stomach. The research highlighted CYLD's role as a tumor suppressor and its importance in maintaining organ homeostasis and preventing aging. The overactivation of the NF-κB pathway and increased inflammation were linked to these effects. The study also emphasized CYLD's crucial role in hair follicle homeostasis and hair growth, with its deficiency leading to abnormal hair growth cycles and alopecia.