TLDR Lack of functional CYLD in mice leads to early aging and cancer.
The study investigated the role of the tumor suppressor CYLD in premature aging and cancer development using transgenic mice expressing a mutant form of CYLD lacking deubiquitinase function. These K5-CYLD<sup>C/S</sup> mice exhibited significant alterations in the epidermis, hair follicles, and sebaceous glands, and showed signs of premature aging, such as alopecia and kyphosis, as early as 3 months old. Histological analysis revealed accelerated aging in multiple organs, including the skin, thymus, pancreas, liver, and lung. The mice also spontaneously developed tumors of various origins. The study suggested that the over-activation of the NF-κB pathway, along with hyperactivation of Akt, JNK, and c-Myc, and chronic inflammation, were mechanisms contributing to the observed premature aging and tumor development.
99 citations
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June 2005 in “Journal of Cosmetic Dermatology” Hair ages due to genetics and environmental factors, leading to graying and thinning, with treatments available for some conditions.
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April 2001 in “Current Biology” c-Myc activation in mouse skin increases sebaceous gland growth and affects hair follicle development.
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,
May 2022 in “Cell discovery” The study found new details about human hair growth and suggests that preventing a specific biological pathway could potentially treat hair graying.
