research Coinheritance of BRCA2 and CYLD Germline Pathogenic Variants Associated with Targetable Metastatic Malignant Cylindroma
Coinheritance of BRCA2 and CYLD genes may lead to new treatment options for certain cancers.
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5 / 43 results research Premature Aging and Cancer Development in Transgenic Mice Lacking Functional CYLD
Lack of functional CYLD in mice leads to early aging and cancer.
research Comparative Ubiquitinomics of Human Skin Reveals Insulin Receptor Ubiquitination as a Regulator of Collagen Secretion
Ubiquitination of the insulin receptor regulates collagen secretion in human skin.
research CENPV Is a Novel CYLD-Interacting Molecule Regulating Ciliary Acetylated Tubulin
CENPV, a new partner of CYLD, helps regulate ciliary acetylated tubulin and is overexpressed in certain skin tumors.
research CYLD Cutaneous Syndrome Tumors Demonstrate Increased NF-kB Signaling and Diminished Collagen Organization
Skin tumors with CYLD cutaneous syndrome show more NF-κB activity and less organized collagen.
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