The Prostaglandin Synthases, COX-2 and L-PGDS, Mediate Prostate Hyperplasia Induced by Low-Dose Bisphenol A

The study demonstrated that low-dose bisphenol A (BPA) exposure induced prostate hyperplasia in male Sprague–Dawley rats, with significant effects observed at 30 µg/kg. BPA exposure increased prostate size, glandular secretions, and cell proliferation while decreasing apoptosis, mediated by upregulation of prostaglandin synthases COX-2 and L-PGDS. These enzymes were linked to changes in hormone levels and increased NF-κB p65 expression, suggesting their role in BPA-induced hyperplasia. Inhibitors of COX-2 and L-PGDS reduced these effects, indicating their potential as therapeutic targets. The study involved 50 rats, divided into five groups, and highlighted the need for further research to confirm these findings.