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Researchers found new potential treatments for conditions related to the androgen receptor, like male hormonal contraception, by testing thousands of compounds.

A new compound effectively inhibits human 5α-reductase 1.

Dutasteride and finasteride affect different cell types differently.

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

Understanding how androgens work is key for creating new treatments for prostate issues and hair/skin conditions.

Certain Dibenzo derivatives may help treat prostate cancer.

Fluridil promotes hair growth safely and effectively for androgenetic alopecia.

Germacrene analogs, especially 8-Hydroxy germacrene B, are more effective than germacrone at blocking a hormone-related enzyme and could help treat hair loss.

The new compound was more effective than finasteride in reducing markers of hair loss and prostate issues in cell tests.

Melanocyte-associated antigens may play a key role in alopecia areata and could be targets for new treatments.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Androgens may cause hair loss by increasing TGF-beta1 from scalp cells, which inhibits hair cell growth.

Shorter CAG repeats may cause hair and skin issues, while longer ones may link to acne.

Androgens can help prevent memory problems caused by apoE4.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

Male pattern hair loss could hint at androgens affecting COVID-19 severity.

Male pattern baldness involves hormones and cell signals affecting hair growth.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

Inhibiting 5α-reductase can help reduce prostate cancer risk and improve treatment.

FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.

No treatment fully prevents hair loss from chemotherapy yet.

Scientists made the first metal-based compounds from a nonsteroidal antiandrogen drug, which showed potential in fighting both hormone-dependent and independent prostate cancer cells.