Design, Synthesis and Anti-Tumor Evaluation of Novel Thiohydantoin Congeners as Androgen Receptor Antagonists With In Vivo Study

    May 2024 in “ Journal of molecular structure ”
    Nada M. Mohamed, Shaimaa I. El Rabeeb, Moshira A. El Deeb, Amal M. Mahfoz, Fatma G. Abdulrahman
    Image of study
    TLDR A new compound, 3a, effectively fights prostate cancer better than finasteride.
    The study focused on designing and synthesizing novel thiohydantoin derivatives as androgen receptor antagonists to treat prostate cancer. The di-cyanide analogues 3a-b and 3d demonstrated significant growth inhibition of androgen-sensitive LNCaP cells with IC50 values ranging from 2.64 to 20.62 µM. Hydrolyzing one cyanide group to an amide maintained activity, while conversion to an ester reduced it. Hydrophobic substitutions on the phenyl moiety improved predicted logP and growth inhibition. The study was self-funded and conducted by the authors without external financial support.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 1000+ results

      community Topical finasteride might be a lie

      in Research/Science 1 year ago
      The conversation discusses doubts about the effectiveness of topical finasteride for hair loss, suggesting that DHT could be produced elsewhere in the body and affect the scalp. It proposes that androgen receptor antagonists like spironolactone and clascoterone might be more effective as they could prevent this potential bypass mechanism.

      community A Technical Question About Pyrilutamide

      in Research/Science  5 upvotes 1 year ago
      Pyrilutamide is believed to be more effective than RU58841 and 1 mg finasteride in treating hair loss, with no systemic hormonal effects and the potential to block more than 31% of scalp DHT. It may also antagonize scalp testosterone due to its action as an androgen receptor antagonist.

      community Overwhelming amount of anti-androgens

      in Female 1 year ago
      The conversation discusses the effectiveness of anti-androgens for hair loss, with a preference for topical treatments like RU58841 over oral options due to better scalp concentration and fewer side effects. Topical finasteride at 0.1% may provide some results, especially when combined with a topical androgen receptor antagonist like RU58841.

    Similar Research

    5 / 1000+ results