Long Non-Coding RNA AL136131.3 Inhibits Hair Growth Through Mediating Glycolysis in Androgenetic Alopecia
May 2023
long non-coding RNA AL136131.3 androgenetic alopecia hair growth miniaturized follicles catagen phase anagen hair follicles PPARγ PKM glycolysis hair shaft growth hair follicle proliferation hair follicle apoptosis lncRNA AGA hair loss hair thinning hair cycle hair growth phase hair death phase PPAR gamma pyruvate kinase M2
TLDR The RNA AL136131.3 slows down hair growth and speeds up hair loss by affecting sugar breakdown in hair follicles.
The study aimed to identify potential long non-coding RNA (lncRNA) indicators for androgenetic alopecia (AGA) and understand the role of AL136131.3 in hair growth. The researchers collected miniaturized and normal follicles from 10 AGA patients for RNA-sequencing. They found 378 mRNAs and 137 lncRNAs differentially expressed between miniaturized and normal follicles. Among these, AL136131.3 was up-regulated in miniaturized follicles. The study found that overexpression of AL136131.3 inhibited hair shaft growth, accelerated hair follicles into the catagen phase, inhibited proliferation, and promoted apoptosis of hair follicles. Additionally, overexpression of AL136131.3 inhibited the transcription of glycolysis-related PPARγ and PKM in anagen hair follicles. Therefore, AL136131.3 might inhibit hair growth and accelerate the hair follicles into catagen through inhibiting the expressions of PFM and PPARγ in AGA.
