Long Non-Coding RNA AL136131.3 Inhibits Hair Growth Through Mediating Glycolysis in Androgenetic Alopecia

April 2023 in “ Journal of Investigative Dermatology ”

X. Liu, Y. Zhang, J. Wang, Q. Liu, W. Wu, J. Lin

long non-coding RNA AL136131.3 androgenetic alopecia miniaturized hair follicles fructose metabolism mannose metabolism hair shaft growth catagen phase glycolysis PPARγ PKM AGA hair loss hair growth inhibition

Studysummary This study found that overexpression of the lncRNA AL136131.3 may inhibit hair shaft growth and promote hair follicle apoptosis in androgenetic alopecia by influencing key metabolic pathways. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigates the role of long non-coding RNA AL136131.3 in androgenetic alopecia (AGA) by analyzing miniaturized and normal hair follicles from 10 AGA patients. It identifies 378 mRNAs and 137 lncRNAs with differential expression between these follicles. AL136131.3, among others, is up-regulated in miniaturized follicles and is linked to fructose and mannose metabolism pathways. The study finds that overexpression of AL136131.3 inhibits hair shaft growth, accelerates the transition of hair follicles into the catagen phase, and affects glycolysis-related genes PPARγ and PKM, suggesting its inhibitory role in hair growth in AGA.

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