TLDR Long non-coding RNAs play a role in hair growth stages of Hetian sheep, affecting wool quality.
This study examined the molecular mechanisms of hair follicle development in Hetian sheep, focusing on the role of long non-coding RNAs (lncRNAs) during different growth stages. Using RNA-Seq technology, researchers analyzed hair follicles from three 12-month-old female Hetian sheep across anagen, catagen, and telogen phases. They identified significant differential expression of lncRNAs and mRNAs, with 41 lncRNAs upregulated and 157 downregulated during anagen compared to telogen. Key genes like KIF7, KRT84, and HOXB5 were associated with hair characteristics. The study highlighted the involvement of the Hedgehog and AMPK signaling pathways, suggesting potential regulatory roles of lncRNAs in hair follicle cycle regulation. This research provides insights into improving wool quality and yield in Hetian sheep and lays the groundwork for future molecular studies.
54 citations
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April 2019 in “Journal of cellular physiology” miR-218-5p helps skin and hair growth by targeting SFRP2 and activating a specific signaling pathway.
129 citations
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October 2017 in “BMC Genomics” The study on cashmere goats (Capra hircus) provided insights into the roles of coding genes, miRNAs, and lncRNAs in hair follicle development and cycling. Researchers identified 1,108 lncRNAs and 541 miRNAs during the anagen and telogen phases, with significant differential expression observed. The study highlighted the functional conservation of lncRNAs and identified miRNA-mRNA and miRNA-lncRNA interactions, constructing ceRNA networks that illustrated their roles in hair follicle biology. This research expanded the understanding of lncRNA and miRNA biology, contributing to the annotation of the goat genome and providing a foundation for future studies on improving cashmere fiber production.
57 citations
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November 1998 in “Wound Repair and Regeneration” Hair papilla cells can create and regenerate hair bulbs under the right conditions.
August 2024 in “Current Issues in Molecular Biology” Key genes and RNAs related to hair growth in sheep were identified, aiding future breeding improvements.
22 citations
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April 2017 in “Journal of Investigative Dermatology” Non-coding RNAs are crucial for skin development and health.
16 citations
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January 2021 in “BMC Genomics” Higher hair follicle density leads to more wool in rabbits, influenced by specific genes and lncRNAs.
August 2019 in “Research Square (Research Square)” Certain long non-coding RNAs in cashmere goats affect hair growth when treated with a specific growth factor.
July 2023 in “Indian Journal of Animal Health” FGF-5 promotes Cashmere goat hair growth by increasing keratin genes and reducing certain LncRNA and target genes.
7 citations
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October 2023 in “BMC Genomics” Noncoding RNAs help determine cashmere quality in goats.
