Analysis of Differential Expression of Hair Follicle Tissue Transcriptome in Hetian Sheep Undergoing Different Periodic Changes

    November 2024 in “ PeerJ ”
    Xueyan Chen, Shengming Sun, Yiming Sulaiman
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    TLDR Long non-coding RNAs play a role in hair growth stages of Hetian sheep, affecting wool quality.
    This study examined the molecular mechanisms of hair follicle development in Hetian sheep, focusing on the role of long non-coding RNAs (lncRNAs) during different growth stages. Using RNA-Seq technology, researchers analyzed hair follicles from three 12-month-old female Hetian sheep across anagen, catagen, and telogen phases. They identified significant differential expression of lncRNAs and mRNAs, with 41 lncRNAs upregulated and 157 downregulated during anagen compared to telogen. Key genes like KIF7, KRT84, and HOXB5 were associated with hair characteristics. The study highlighted the involvement of the Hedgehog and AMPK signaling pathways, suggesting potential regulatory roles of lncRNAs in hair follicle cycle regulation. This research provides insights into improving wool quality and yield in Hetian sheep and lays the groundwork for future molecular studies.
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