TLDR FGF-5 promotes Cashmere goat hair growth by increasing keratin genes and reducing certain LncRNA and target genes.
The study investigated the role of long non-coding RNA (LncRNA) in hair growth of Liaoning Cashmere goats using RNA sequencing. It was found that fibroblast growth factor 5 (FGF-5) at a concentration of 10^-4 g/L for 72 hours (F4_72H) was optimal. FGF-5 suppressed LncRNA expression in skin cells, reduced the expression of target genes CBS and CTH, and increased the expression of keratin genes k26 and kap11.1. This suggests that FGF-5 may regulate Cashmere hair growth by promoting keratin and keratin-associated protein genes while suppressing LncRNA and target genes CBS and CTH.
28 citations,
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December 2002 in “Journal of biological chemistry/The Journal of biological chemistry” Researchers mapped and categorized specific keratin-associated protein genes on human chromosome 21q22.1.
August 2019 in “Research Square (Research Square)” Certain long non-coding RNAs in cashmere goats affect hair growth when treated with a specific growth factor.
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2 citations,
July 2023 in “Animals” FGF10 and non-coding RNAs are important for cashmere goat hair follicle development.
